CYP450 inhibition

Inhibitory potency (IC50) provides invaluable information regarding drug interaction potential. The IC50 of test compound against the seven FDA recommended CYP450 metabolizing enzymes is determined using specific drug probe substrates. Analysis is by LC-MSMS. 

Deliverable: IC50 (μM) of test compound against CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 & CYP3A4 (Midazolam & Testosterone).

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