Probing low viscosity and weakly-structured complex fluid formulations using DLS microrheology

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00:00:00 Introduction to DLS Microrheology and its Applications
00:01:43 Introduction to DLS Micro-rheology and its Applications
00:01:57 Overview
00:02:36 Microrheology
00:03:23 Benefits of Microrheology
00:04:29 DLS Microrheology
00:05:32 Brownian Motion, Particle Size and Viscosity
00:05:32 Brownian Motion, Particle Size and Viscosity
00:05:51 DLS Instrument Components
00:07:21 Correlation in Dynamic Light Scattering
00:07:32 Correlation in Dynamic Light Scattering
00:08:06 Correlation: Low viscosity gives rapid fluctuations
00:08:49 Correlation:Low Viscosity, Rapid fluctuations
00:09:10 Correlation:Low Viscosity, Rapid Fluctuations
00:09:35 Correlation:Low Viscosity, Rapid Fluctuations
00:09:42 Correlation:Low Viscosity, Rapid Fluctuations
00:09:44 Correlation:Low Viscosity, Rapid Fluctuations
00:10:05 Intensity Fluctuations and Brownian Motion
00:10:32 Correlation Functions
00:11:40 Mean Square Displacement
00:12:23 MSD Time Dependence
00:12:23 Extraction of Rheological Data
00:16:51 Extraction of Rheological Data
00:18:06 Extraction of Rheological Data
00:20:59 Extraction of Rheological Data
00:20:59 Making a Measurement
00:24:21 Ensuring Single Scattering
00:26:15 Evaluating Sample/Tracer interaction
00:28:10 Effect of probe chemistry – protein solution (BSA)
00:30:39 Tracer Size Measurement
00:31:51 Rotational Rheometry - A complementary tool
00:33:33 Rotational Rheometery – A complementary tool
00:34:15 Effect of Particle Size on Frequency Range
00:35:56 Example 1 – Polyacrylamide Solution
00:38:22 Example 2 – Shear thinning of Protein solutions
00:40:30 Example 3 - Denaturation of Protein solution
00:42:07 How to get DLS Microrheology?
00:43:59 Conclusions
00:45:31 Any Questions?
00:55:43 Contact Information

This webinar is of interest to anyone involved in the rheological testing of complex fluid formulations which are low viscosity and weakly-structured. DLS microrheology is a technique which is particularly applicable to polymers and proteins in solution, where access to high frequency data extends the viscoelastic measurement range into process-relevant timescales, and is key to understanding short timescale dynamics of these systems. The webinar discusses the basic principles behind DLS Microrheology with relevant application examples relating to proteins and polymer solutions.