Date recorded: July 26 2016

Duration: 47 minutes 45 seconds

Understanding the stability of biological formulations – including their propensity to aggregate - is one of the primary requirements of moving drug candidates through the development pipeline. Biopharmaceutical companies will often establish a target molecule profile, with the intention of ensuring that poor candidates are removed from the development process as early as possible. 

Formulation stability and aggregation potential are core properties for the target molecule profile, to ensure an acceptable drug shelf life, good efficacy and safety profiles, and to minimize the risk of unwanted particle formation.

This presentation introduces the complementary nature of Taylor Dispersion Analysis (TDA) as a method of measuring protein size and understanding the aggregation potential of a biological formulation.

Table of contents
1. Welcome
01:23
2. Welcome
00:31
3. The role of Taylor Dispersion Analysis in assessing the stability of biological formulations
00:35
4. Abstract
00:47
5. Proteins as Therapeutics
00:18
6. Proteins as Therapeutics
01:46
7. Proteins as Therapeutics
00:06
8. Proteins as Therapeutics
00:24
9. Proteins as Therapeutics
00:54
10. Proteins as Therapeutics
00:47
11. Proteins as Therapeutics
00:14
12. Proteins as Therapeutics
02:02
13. The Target Molecule Profile
01:05
14. The Target Molecule Profile
00:13
15. The Target Molecule Profile
00:11
16. The Target Molecule Profile
00:08
17. Screening Techniques
01:29
18. Screening Techniques
01:40
19. Screening Techniques
02:05
20. A Complimentary Screening Technique
01:41
21. A Complimentary Screening Technique
02:57
22. Taylor Dispersion Analysis
00:53
23. Taylor Dispersion Analysis
02:43
24. Taylor Dispersion Analysis
01:50
25. Taylor Dispersion Analysis
01:39
26. Taylor Dispersion Analysis - Summary
01:13
27. Volume vs Intensity
00:46
28. Some practical examples
00:04
29. Taylor Dispersion Analysis - Proteins
02:13
30. Taylor Dispersion Analysis - Proteins
01:56
31. Taylor Dispersion Analysis - Proteins
03:31
32. Taylor Dispersion Analysis - Proteins
01:06
33. Conclusions
01:29
34. Thank you for your attentionAny questions?Please type your questions in using the Q&A panel on the right side of your screen
06:32
35. Thank you
00:34