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Application notes describe the application of one or more of our analytical methods to resolve issues or answer questions.

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A variety of aqueous (water-soluble) cellulose derivatives were characterized using the OMNISEC triple detection GPC/SEC system which revealed subtle, yet distinct differences between them. The differences described in this application note could be used in the pharmaceutical industry to correlate their molecular properties with performance.

Products:
OMNISEC system
Date:
February 3 2015
Language:
English

In some industries, for example, in early-stage pharmaceutical development, it is desirable to measure particle size from a small samples of dry powders. However measuring small quantities risks measuring a sample that is not representative of the bulk material. In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.

Products:
Mastersizer 3000
Date:
February 6 2015
Language:
English

A series of dextran samples ranging in molecular weight from about 1– 650 kDa are characterized using OMNISEC. Structural comparisons to other polysaccharides, gum arabic and pectin are presented

Products:
OMNISEC system
Date:
April 15 2015
Language:
English

Learn how ITC can be used to guide protein (RNA)/ligand crystallization and to resolve common issues with crystallization of complexes.

Polymorphic conversions are an ongoing problem in the pharmaceutical industry. Here we describe the use of Morphologically-Directed Raman Spectroscopy (MDRS®), available on the Morphologi® ID, to distinguish and quantify particles of different polymorphic types of acetaminophen (paracetamol) within a mixture. MDRS is a flexible tool for root cause analysis, product quality and formulation development and is well-suited to identifying even low-level polymorphic contamination.

Products:
Morphologi 4-ID
Date:
June 22 2015
Language:
English

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