The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.

Understanding molecular weight determination, absolute molecular weight measurement and other molecular parameters is key to controlling product performance in a wide variety of applications areas including:

  • Strength, durability and toughness of plastics and other synthetic polymers.
  • Degradation and release rate of drug delivery polymers.
  • Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives.
  • Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives.
  • Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs).

Malvern Panalytical’s advanced GPC/SEC detectors, which include low angle and right angle light scattering (LALS and RALS) and multi-angle light scattering (SEC-MALS), are designed to measure absolute molecular weight with unparalleled accuracy. Complete systems such as the TDAmax form an out-of the-box solution, while add-on detectors such as the SEC-MALS 20 and the Zetasizer µV allow you to upgrade an existing GPC/SEC system to measure absolute molecular weight.

OMNISEC

OMNISEC

The world’s most advanced multi-detector GPC/SEC system

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Measurement Molecular structure, Molecular size, Molecular weight
Molecular weight range 200Da - 10MDa
Minimum sample mass (polystyrene) 100ng
Minimum sample mass (BSA) 100ng
Technology Gel Permeation Chromatography, Size Exclusion Chromatography (SEC), Light Scattering, Static Light Scattering

Zetasizer range

Zetasizer range

The world’s most widely-used systems for nanoparticle, colloid and biomolecular particle sizing and particle charge measurements

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Measurement Molecular size, Molecular weight, Particle size, Zeta potential
Temperature range 0°C - 120°C
Particle size range 0.3nm - 10µm
Technology Light Scattering, Dynamic Light Scattering, Electrophoretic Light Scattering, Static Light Scattering
Dispersion type Wet
Sample cell type Cuvette
Molecular measurement type Chromotography, Batch measurement

Empyrean Nano Edition

Empyrean Nano Edition

Versatile X-ray scattering platform

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Measurement Molecular weight, Particle shape, Particle size, Surface area, Protein aggregation, Protein stability, Phase identification, Phase quantification, Pore size distribution
Goniometer configuration Vertical goniometer, Θ-Θ
Particle size range 1 - 100 nm
Technology X-ray Diffraction (XRD), X-ray Scattering

OMNISEC

OMNISEC

The world’s most advanced multi-detector GPC/SEC system

Zetasizer range

Zetasizer range

The world’s most widely-used systems for nanoparticle, colloid and biomolecular particle sizing and particle charge measurements

Empyrean Nano Edition

Empyrean Nano Edition

Versatile X-ray scattering platform

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Measurement Molecular structure, Molecular size, Molecular weight Molecular size, Molecular weight, Particle size, Zeta potential Molecular weight, Particle shape, Particle size, Surface area, Protein aggregation, Protein stability, Phase identification, Phase quantification, Pore size distribution
Molecular weight range 200Da - 10MDa    
Minimum sample mass (polystyrene) 100ng    
Minimum sample mass (BSA) 100ng    
Temperature range   0°C - 120°C  
Particle size range   0.3nm - 10µm 1 - 100 nm
Goniometer configuration     Vertical goniometer, Θ-Θ
Technology Gel Permeation Chromatography, Size Exclusion Chromatography (SEC), Light Scattering, Static Light Scattering Light Scattering, Dynamic Light Scattering, Electrophoretic Light Scattering, Static Light Scattering X-ray Diffraction (XRD), X-ray Scattering
Dispersion type   Wet  
Sample cell type   Cuvette  
Molecular measurement type   Chromotography, Batch measurement  

OMNISEC

Zetasizer Advance Range

Empyrean Nano Edition

OMNISEC Zetasizer Advance Range Empyrean Nano Edition

The world’s most advanced multi-detector GPC/SEC system

Light Scattering for every application

Versatile X-ray scattering platform

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Measurement type
Molecular structure
Molecular size
Molecular weight
Technology
Gel Permeation Chromatography
Size Exclusion Chromatography (SEC)
Dynamic Light Scattering
X-ray Diffraction (XRD)