The Zetasizer Nano S90 is the perfect lower cost solution when the ultimate in sizing sensitivity is not necessary, or where identical results to a legacy system with 90 degree scattering optics are required.

  • Size measurement from 0.3nm (diameter) to 5 microns using 90 degree scattering optics.
  • Molecular weight measurement down to 9,800Da.
  • A ‘Quality Factor’ and ‘Expert Advice System’ gives the confidence of having an expert at your shoulder.
  • 21CFR part 11 software option enables compliance with ER/ES.
  • Research software option gives access to further features and analysis algorithms for the light scattering specialist.
  • Automation of measurements using an autotitrator option.
  • Alternative laser, 50mW at 532nm for samples incompatible with the standard 633nm laser fitted.
  • Optical filter option to improve measurements with fluorescent sample.
  • Temperature range extension option to 120°C.
  • Systems can be upgraded to add zeta potential at a later date.

The Zetasizer Nano S90 incorporates two techniques in a single compact unit, and has a range of options and accessories to optimize and simplify the measurement of different sample types.

Dynamic Light Scattering is used to measure particle and molecule size. This technique measures the diffusion of particles moving under Brownian motion, and converts this to size and a size distribution using the Stokes-Einstein relationship.

Static Light Scattering is used to determine the molecular weight of proteins and polymers. In this technique, the scattering intensity of a number of concentrations of the sample is measured, and used to construct a Debye plot. From this the average molecular weight and second virial coefficient can be calculated.
This measurement is very demanding on the stability of the whole system, and means that every element of the design has been optimized to ensure accuracy and repeatability

Software
The software is designed to be versatile and rich in features without compromising ease of use. Standard Operating Procedures (SOP) simplify routine measurements, a quality factor gives a single place to look for the success of a measurement, and expert advice is given to assist with data interpretation.

Options
The MPT-2 Autotitrator enables the study of the effect of changes in pH, conductivity, or any additive to be automated.

A range of disposable and reusable cells are available to optimize the measurement in terms of sample volume, concentration and for flow measurement.

Other options include filters to improve the measurement of fluorescent samples, a temperature range extension to 120ºC and a viscometer to determine the sample viscosity to the accuracy required for the techniques used.

Particle size and molecular size.

Measurement range:
0.3nm – 5.0 microns* (diameter).
Measurement principle:
Dynamic Light Scattering.
Minimum sample volume:
20µL.
Accuracy:
Better than +/-2% on NIST traceable latex standards.
Precision / Repeatability:
Better than +/-2% on NIST traceable latex standards.
Sensitivity:
10mg/mL (Lysozyme)

Molecular weight.

Measurement range:
Molecular weight
Measurement principle:
Static Light Scattering using Debye plot.
Minimum sample volume:
20µL (3-5 sample concentrations required).
Accuracy:
+/- 10% typical
Temperature control range:
0°C - 90°C +/-0.1**, 120°C option.
Light source:
He-Ne laser 633nm, Max 4mW.
Laser safety:
Class 1.
Power:
100VA.

Weight and dimensions:

Dimensions:
320mm, 600mm, 260mm (W,D,H).
Weight:
21 (kg)

Operating environment:

Temperature range:
10°C – 35°C.
Humidity:
35% - 80% non-condensing.

Notes:

*:
maximum range, sample dependent
**:
at 25°C.
Patents:
The Zetasizer Nano range is protected by the following patents: Non-Invasive Back Scatter (NIBS) EP884580, US6016195, JP11051843 High and Low Frequency Electrophoreses (M3) EP1154266, US7217350, JP04727064 Light Scattering Measurements using Simultaneous Detection EP2235501, CN102066901, JP2011523451, US20090251696 Surface Potential Determination in a Dip Cell WO2012172330
A range of accessories are available to make life easier, or to add capability to the system.

Zetasizer Nano S90

Accessories

NanoSampler

Automated particle size measurement for the Zetasizer Nano

Image

The Zetasizer NanoSampler is a sample delivery system that ensures highly precise and reproducible automated loading of samples into your Zetasizer Nano. The NanoSampler adds automation and unattended operation in a versatile, compact package, maximising the productivity of your Zetasizer Nano. While the benefits of automated operation are useful for all users, the NanoSampler is ideally suited for laboratories where a large number of measurements are required and reproducibility or multi-variate studies are important.

More information

MPT-2

Simplify pH, conductivity and additive titrations on your Zetasizer Nano

Image

A cost effective accessory designed to automate the measurement of size and zeta potential as a function of pH, conductivity or any soluble additive.

More information

SV-10 viscometer

Viscosity measurement with speed, simplicity and accuracy.

Image

The SV-10 measures viscosity with the accuracy required for dynamic light scattering, for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential, in an extremely simple and rapid system.

More information

Cell and cuvette options

Quartz flow cell (ZEN0023)

Add flow capability for size measurements to the Zetasizer.

  • Measure size and intensity with MPT-2 autotitrator.
  • Connect to an SEC system to use as a DLS detector.
Visit store to buy now

12mm Glass cell (PCS1115)

Glass cuvette for use with the dip cell.

  • For size and zeta potential measurements using the ‘dip’ cell.
  • Compatible with aqueous and non-aqueous solvents and dispersants.
Visit store to buy now

12mm Square Polystyrene Cuvettes (DTS0012)

Disposable polystyrene cuvettes.

  • 100 disposable cells complete with 100 stoppers to avoid cross contamination.
  • For size measurements using aqueous dispersants.
  • Compatible with zeta potential measurements using the dip cell.
Visit store to buy now

12mm square glass cell (PCS8501)

Glass cuvette for batch measurements.

  • For size and molecular weight measurements.
  • Compatible with aqueous and non-aqueous solvents and dispersants.
Visit store to buy now

Low-volume quartz batch cuvette (ZEN2112)

Low-volume quartz batch cuvette for size and molecular weight measurements.

  • Compatible with size and molecular weight measurements with aqueous and non-aqueous solvents and dispersants.
  • Minimum sample volume 12 microliters.
  • Maximum volume 45 microliters.
Visit store to buy now

ZEN0118

Disposable low volume cuvette for size measurement with 90° optics only.

  • 100 x 50µL cuvettes with 100 caps to avoid cross contamination.
  • Compatible with aqueous dispersants.
Visit store to buy now

Factory fitted options

For use where the sample is incompatible with the standard 633nm laser, either because the sample absorbs or fluoresces, or the sample is photosensitive.

This addition of this option does not affect the system specifications.

Useful where the sample fluoresces. Eliminates scattering due to fluorescence to improve the signal to background ratio.

Increases the high temperature capability from 90°C to 120°C. Suitable for samples in wax media that melt above 90°C.

Titrants used by the MPT-2 titrator need regular degassing, ideally before each titration.

Degassing is required to remove bubbles that can affect the volume of titrant dispensed. This is particularly important close to pH 7 where low volumes of titrant are required.

The degasser is a highly recommended ‘Fit and forget’ accessory that continuously degasses titrants which improves the speed of titrations and the accuracy of reaching the target pH. This gives more evenly spaced pH points.

Visit store to buy now

Protect your investment and ensure optimized performance at all times with Malvern’s service plans.

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern will provide the support for your business.

Help Desk

Training

Software downloads

Malvern’s service options- choose the right plan for you:

Malvern Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.

Malvern Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.

Malvern Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum PlanGold PlanBronze Visit
Annual PM/PV Test
yes
yes
no
Telephone / Email Support
yes
yes
no
Priority Response
yes
yes
no
Emergency Breakdown visits*
yes
yes
no
Parts Included
yes
no
no
E-Learning**
yes
yes
no
Technical & Software Support
yes
yes
yes
IQ/OQ (Pharma)***
yes
yes
yes

*including labour & travel costs** Platinum 2 places per contract term, Gold 1 place per contract term***available at an additional cost