Therapeutic area expertise

CLS-logo.png From bench-to-bedside, Concept Life Sciences has extensive experience in providing immunology, oncology and neuroscience CRO services to clients discovering and developing new medicines, including small molecule, biologic and cell therapies.

Collaborative and tailored programs of work to our clients' requirements

Concept Life Sciences applies knowledge and data from fundamental biology, pre-clinical research and clinical trials to ensure our clients’ discovery pipelines address critical, unmet needs.

We work collaboratively and tailor our programs of work to our clients’ requirements, whether that’s customizing our assays to suit target pathways, or designing novel assays.

Our state-of-the-art facilities feature the latest laboratory equipment and cutting-edge technology, such as the IncuCyte® Live Cell Analysis System for visualization and quantification of cell behavior over time and Cytiva’s Biacore 8K and T200 SPR Systems, allowing us to deliver high throughput, quality binding data when screening and characterizing small molecules and biologics, enhancing our biophysical capabilities. Our specialist histology facilities include the Akoya Biosciences® Vectra® Polaris™ Automated Quantitative Pathology Imaging System, capable of multispectral imaging of up to nine markers on one section (9-plex), and we also have access to further specialist equipment (e.g. the NanoString nCounter® Analysis System) through our close academic links.

We have Attune NxT Acoustic Focusing Cytometers which allow for up to 11 color medium-throughput screening and we are also able to use our Bio-Rad S3™ Cell Sorter for multi-color cell sorting for use in downstream assays such as the nTreg suppression assay. This represents just a snapshot of our extensive biology equipment and techniques.

Our services include designing custom in vitro immune cell-based assays for biomarker discovery, target expression and MOA (mechanism of action) studies.

Immunology

We offer CRO services to biotech and pharmaceutical companies developing treatments for a range of autoimmune diseases.

We can tailor immunology screening programs to discover the mechanisms of action (MOA) of your drug candidate for treating autoimmune disease. Such programs often involve a phenotypic screen in which specific cell types (e.g. T cells) are studied in the presence of the test compound(s).

Beyond our in vitro expertise, we offer novel, biologically relevant in vivo models of autoimmune disease, as well as off-the-shelf models for routine screening.

Assays for all immune cell types

  • Mixed lymphocyte reactions (MLRs)
  • PBMC and T cell stimulation assays
  • Exhausted T cell assay
  • Killing assays
  • Suppression assays
  • Phagocytosis assays
  • Myeloid cell assay
  • Bespoke in vivo models

For more detail on these assays and more please visit our immunology pages.

Liver Fibrosis services

Our scientific team has specialist expertise in fibrosis research. Leveraging this know-how, combined with our expertise in immunology, we are developing a suite of in vitro, ex vivo and in vivo assays with customizable end-points to study fibrosis e.g. transition assays using primary hepatic stellate cells (HSCs) and precision cut liver slices.

Immuno-oncology services

A hallmark of cancer is its characteristic immunosuppressive immune environment.

We can design specialized assays and programs of work to understand immune function in the tumor microenvironment and how this might be manipulated therapeutically by either antibodies, small molecules oncolytic virus’ or combinations of these. Assays are validated with benchmark controls.

We have an extensive array of read-out techniques as well as RNA sequencing and specialist multiplex histology experience. Our suite of available immuno-oncology services and assays can be specifically tailored to your project:

  • Human Mixed Lymphocyte Reactions (MLRs)
  • Exhausted CD4+ T cell Assay
  • Suppression Assays
  • Killing Assays
  • Human Tumour Ex Vivo Systems
  • PBMC and T Cell Stimulation Assays
  • Exhausted T Cell Assays
  • Phagocytosis Assays
  • Myeloid Cell Assays

For more detail on these assays and more please visit our immuno-oncology and oncology pages 

Neuroscience

Our experienced Neuroscience team offer specialist discovery services to clients looking to develop novel therapies for a range of neurodegenerative conditions. We can tailor and develop neuroprotective screening assays to discover the mechanism of action of your drug candidate, with customized assays targeting neurons themselves and/or the supportive glial cells in isolation or co-culture.

  • Primary CNS assays
  • Organotypic Brain Slice Assays
  • Human CNS iPSC Assays
  • Specialist in vivo models

For more detail on these assays and more please visit our neuroscience pages.

We are developing a range of neurotoxicity services, including developmental neurotoxicity assays (DNT), using our pluripotent stem cell and primary CNS cell-based assay platforms that can support Pharma and non-Pharma clients in their regulatory and safety requirements.

Multiple sclerosis services

We have world-leading expertise in research into multiple sclerosis (MS), a disease that requires understanding of immunology, inflammation and neuroscience.

We can provide end-to-end support for MS drug discovery. We offer a suite of in vitro assays for clients seeking to reduce disease progression in MS by improving remyelination efficiency. These include an Oligodendrocyte Precursor Cell (OPC) culture assay to assess the effects of a test substance on differentiation and cell survival.

Following compound screening in our OPC assay, your lead compound can be progressed to our Central Nervous System (CNS) slice model to assess functional remyelination efficiency following toxin-induced demyelination. This model is a powerful screening tool for potential translational tool linking in vitro assays and in vivo studies.

Our range of in vivo MS services allow lead compound assessment in models such as the EAE, cuprizone and LPC MS models.

Concept Life Sciences Biology Services Virtual Tour

Take a glimpse into our world! Join us for a short walkthrough of our translational biology services site in Edinburgh, UK. 

Meet our brilliant scientists as they introduce you to our state-of-the-art facilities, and explain how our capabilities and expertise – with an emphasis on neuroscience and neurodegeneration, histology, immunology and immuno-oncology - can accelerate your drug discovery and development workflow.