"Step into the Light" - how dynamic light scattering can improve the quality of your biopharmaceutical data

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00:00:00 Untitled
00:01:08 Step into the Light – how Dynamic Light Scattering can Improve the Quality of your Biopharmaceutical DataMichael CavesProduct Technical Specialist for Biophysical Characterisation
00:01:28 Protein Evolution
00:02:16 Protein Structure
00:02:32 Biopharmaceutical Analysis
00:02:53 Biopharmaceutical Analysis
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00:04:09 Static Light Scattering (SLS)
00:04:32 Dynamic Light Scattering (DLS)
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00:06:38 The Correlogram
00:07:03 The Correlogram
00:08:17 Untitled
00:09:06 Untitled
00:11:26 Dynamic Light Scattering Theory Summary
00:11:52 Untitled
00:11:55 FDA Draft Guidance 2013 – Immunogenicity
00:12:20 Biopharmaceutical Stability
00:13:33 Monitor the Earliest Stages of Aggregation25.0 °C71.5 °C76.5 °C84.0 °C
00:15:02 Pegylation Analysis
00:16:57 Real-Time Aggregation
00:17:52 Antibody Binding Studies
00:18:46 Antibody Binding Studies
00:20:25 Purity and Stability Analysis Summary
00:20:51 Untitled
00:20:53 FDA Draft Guidance 2013 – Immunogenicity
00:21:30 Untitled
00:22:43 Untitled
00:23:34 Untitled
00:24:41 Orthogonal Stability Prediction
00:25:19 Stability Prediction Summary
00:25:37 Untitled
00:25:40 The Malvern Zetasizer Range
00:26:59 DLS Biopharmaceutical Applications
00:27:49 Thank You for ListeningQuestions?
00:31:56 Contact Information
Biopharmaceutical impurities have long been associated with undesirable clinical reactions. It is essential, therefore, that the purity profiles of such drugs are characterized with the most sensitive analysis methods available. Dynamic light scattering is widely used for this purpose, due to its high sensitivity to larger particles, and its ability to resolve trace amounts of such particles from smaller entities (such as the API monomer). In addition, the DLS-derived dynamic virial coefficient can be used as a predictor of aggregation propensity, highly useful for formulation screening. This webinar will investgate how and why the Zetasizer range of instruments is widely used to carry out such types of analysis.