Malvern Instruments is proud to be a premier sponsor of the inaugural PEGS China meeting. The PEGS China Protein & Antibody Engineering and Development summit is presented by Cambridge Healthtech Institute and takes place in Shanghai from 1 - 3 April 2014. Malvern is participating in both the conference and the associated exhibition, with Dr Wei Qi, Senior Scientist within Malvern’s Bioscience Development Initiative, presenting a paper on ‘Emerging techniques for therapeutic protein characterization – viscosity, stability and sub-visible particles’.
Dr Wei Qi’s presentation is on 1 April, contributing to the ‘Analytical characterization and stability’ conference track, and will explore novel techniques for protein therapeutics characterization. He will describe how, using less than 10 μL sample, it is possible to measure viscosity up to 160 cP contemporaneously with concentration up to 200 mg/mL. He will also talk about the novel combination of Raman Spectroscopy and Dynamic Light Scattering (DLS) for the simultaneous characterization of protein secondary and tertiary structure, and hydrodynamic size at high concentration. This new technology enables the assessment of conformational and colloidal stabilty under applied stresses, which is extremely useful when comparing different candidate bioformulations.
As part of the associated exhibition, Malvern will present instruments from the company’s rapidly advancing analytical toolkit for biopharmaceutical development. Established solutions, such as Viscotek size exclusion chromatography systems for assessing product purity and the Zetasizer range for sizing and zeta potential analysis for product stability, sit alongside exciting new technologies. The Viscosizer 200, for example, which is used to assess bioformulation suitability and stability as early as late stage discovery, Archimedes, which uses the technique of resonant mass measurement for counting and measuring sub-micron and sub-visible aggregates and differentiating them from contaminants such as silicone oil in pharmaceutical formulations, and the Nanosight range of Nanoparticle Tracking Analysis instruments to quantify early protein aggregation.
For information about PEGS China visit http://www.pegsummitchina.com
Find out more about Malvern’s Bioscience Development Initiative (BDI) at http://www.malvern.com/bdi
Malvern, Malvern Instruments, NanoSight, Viscotek, Viscosizer and Zetasizer are registered trademarks of Malvern Instruments Ltd