International Symposium on GPC/SEC and Related Techniques

The International Symposium on GPC/SEC and Related Techniques will be held in Philadelphia, PA - USA on October 20 - 22, 2015.

We are sponsoring this unique event on the scientific calendar which focuses on bringing together the three key elements of Instrumentation Innovation, Industrial Research and Academia. 

Thursday, October 22 at 11:20: Mark Pothecary our Product Manager will give a lecture on "Latest Developments in Hardware and Applications for Advanced, Multi-detector GPC/SEC

Join us at the Grand Ballroom for the poster session at 10am and 3pm each day. The psoter is focusing on "Analysis of PLGA molecular weight and structure by the latest advanced multi-detector GPC systems"

Access the full agenda here

We look forward to seeing you there!

Présentateur

Mark Pothecary, Product Manager

Pour en savoir plus

Abstract

Gel-permeation chromatography (GPC) is the most widely used tool for the measurement of molecular weight and molecular weight distribution of polymers.

Static light scattering detectors (whether RALS, LALS or MALS) measure the intensity of light scattered by the sample as it elutes from the column.  Since the intensity of the scattered light is proportional to the sample’s molecular weight and concentration, they allow the direct measurement of the sample molecular weight independent of its elution volume.  Furthermore, the angular dependence of the scattered light is also related to the radius of gyration of the molecule which can also be measured concurrently using a light scattering detector.  The latest developments around light scattering detectors offer a significant improvement in sensitivity to scattered light.   This can be seen in the ability to measure samples with low molecular weight, low concentration and low dn/dc.  Such performance opens up previously difficult application areas including low concentrations of novel polymers, low molecular weight samples such as epoxies, and low dn/dc samples such as the drug delivery molecules, PLA and PLGA.

An intrinsic viscosity detector can also be used as part of a GPC system to measure the parameter of intrinsic viscosity which can be combined with molecular weight data to calculate hydrodynamic radius.  In combination these data allow detailed structural information of a polymer to be generated in a single GPC measurement which can be compared with other samples in Mark-Houwink or Conformation plots.  Viscometers have occasionally been treated with caution by researchers as their maintenance can be expensive but the latest developments in viscometer technology make these concerns a thing of the past.  Disposable capillary bridges and delay columns and automated bridge balancing combine to make viscometers more robust and significantly easier to maintain.

This presentation will introduce OMNISEC, the latest multi-detector GPC/SEC system from Malvern.  It will describe the advances in system design to improve its performance and discuss real-world applications such as those described above, which are benefitting from this performance.