Optimizing the Cost of Protein Research and Development: The Value of Assessing Protein Quality and Stability

Protein researchers often spend weeks engineering, expressing and purifying their protein of interest, only to place it on a shelf in a refrigerator until its needed. The rarely asked question is how long will that sample survive those storage conditions? Protein stability is often not considered during a research project, resulting in lost time and money repeating experiments. The straightforward process of assessing a protein for stability in a set of conditions or adjusting the formulation to improve stability can save valuable time and money during research.

Even when it comes to Viruses, VLPs and vaccine research and development, stability can be the critical point between successful research and failed outcomes.
  
In this workshop, attendees will be introduced to a range of typical analytical workflows that can be used to assess stability and activity. These workflows will include methods used to investigate physical and structural properties, as well as binding and formulation behaviors of samples. By examining and understanding these properties, they can be used to improve the shelf life and consequently improve quality and robustness of any research performed.

This workshop will also include an introduction and demo of the new Zetasizer Ultra. the most intelligent and flexible instrument in the Zetasizer range. Delivering new technologies for insight into protein sizing and stability analysis. Including automated Multi-Angle Dynamic Light Scattering (MADLS®) for higher resolution and more complete particle size distributions, along with calibration-free particle concentration analysis. With the added benefits of deep learning empowered data quality guidance, the new Zetasizer provides intelligent, confident light scattering analysis.


This is a free one-day event from Malvern Panalytical. Seating is limited so don't wait, sign up early to get your seat. Breakfast and Lunch will be provided.

Time

Presentation

9.30 - 10.00am

Arrival and Welcome

10.00 - 10.40 am

Dr. Matthew Brown


Protein Aggregation – Consequences and Avoidance

10.40 - 11.20am

Katherine Bowers from Fujifilm Diosynth


Scientifically driven, high throughput protein formulation development: the
criticality of DSC as a core technique

11.20 - 12.00 am

Dr. Stoyan Milev


From Stability to Activity – Complementary Techniques for
Understanding Protein Activity

12.00 - 1.00 pm

Lunch

1.00 - 1.40 pm

Dr. Arianna Biesso


Zetasizer Ultra – Introduction and Live Demo

1.40 - 2.20 pm

Customer Talk


TBD

2.20 - 3.00 pm

Dr. Arianna Biesso


When Biotherapeutics are Particles: characterize them to
minimize risks