Evaluating aggregation behavior of liposome-protein complexes using NTA

Aggregation of both biological and synthetic materials is a serious cause for concern, posing problems at various stages of the discovery and formulation processes. Liposomes have been used in drug discovery and drug delivery for some time, and the biophysical characterization of these systems and their payloads is critical to understanding their function. One such payload, which we focus on here, is the membrane-associated receptor tyrosine kinase (RTK) targets which continue to be the focus of many discovery campaigns. Our aim is to correlate previously published activity data with the changes in size and aggregation state of the liposome-RTK complex as measured by Nanoparticle Tracking Analysis (NTA).

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