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In this application note, interferon α-5 was conjugated with two different PEG molecules in different reactions. The individual protein and PEG molecules, as well as the PEGylated conjugates are characterized by SEC and their composition, molecular weight and intrinsic viscosity measured. .

Produits:
Viscotek TDAmax
Date:
June 26 2014
Langue:
English
Plus de détails

Les données de DSC sont utiles pour prédire la stabilité d'une protéine en solution. La Tm est une indication de la thermostabilité, et la détermination de la Tm dans différentes formulations est une mesure approximative de la sensibilité à l'agrégation et aux autres changements irréversibles à des températures plus basses..

Produits:
Gamme DSC MicroCal
Date:
June 30 2014
Langue:
French
Plus de détails

Cette note d'application explore principalement les applications de titration calorimétrique isotherme (ITC) dans la recherche sur les inhibiteurs de kinase, mais aborde également le rôle de la calorimétrie différentielle à balayage (DSC) dans le processus de recherche..

Produits:
Gamme ITC MicroCal
Date:
June 30 2014
Langue:
French
Plus de détails

Dans cette note d'application, l'ITC et la DSC ont été utilisées pour caractériser la liaison protéine-excipient, l'une des nombreuses interactions possibles dans une formulation de solution de protéine complexe..

Produits:
Gamme MicroCal
Date:
July 15 2014
Langue:
French
Plus de détails

The aim of formulation development is to design a product and its manufacturing process to consistently deliver the intended Quality Target Product Profile (QTPP). This involves determining the Critical Quality Attributes (CQAs) for the Active Pharmaceutical Ingredient (API) and excipients that define the performance of the product. These are generally identified through an assessment of the extent to which the variation in a specific attribute, for example particle size, can impact the drug product’s quality and performance..

Produits:
Morphologi G3-ID
Date:
August 14 2014
Langue:
English
Plus de détails

This application note shows how a three-step strain/shear rate test can be used to evaluate the rate and extent of elasticity recovery following extrusion from a tube. .

Produits:
Gamme Kinexus
Date:
August 21 2014
Langue:
English
Plus de détails

In this application note, triple detection size exclusion chromatography (SEC-TD) is used to understand the ability of proteins to form ordered, structured complexes. The controlling mechanism behind these protein complexes is fundamental to our knowledge of protein signaling pathways and the physiological responses they control..

Produits:
Gamme Viscotek
Date:
August 21 2014
Langue:
English
Plus de détails

Bacteria fibers are typically monitored with manual microscopy to better understand the effect of environmental factors on their growth. Here, bacteria fibers taken at different times are automatically characterised on the Morphologi G3. Fiber parameters are measured and used to quantitatively differentiate between samples taken at different times. The Morphologi G3 offers significant time savings and decreased subjectivity over the traditional manual optical microscopy method. .

Produits:
Morphologi G3
Date:
October 13 2014
Langue:
English
Plus de détails

Particle size and size distribution are often important parameters in defining product performance. Measuring these at an early stage in development is therefore of significant benefit to researchers who need to engineer specific product attributes. Here we describe how the Hydro SV can support this requirement..

Produits:
Mastersizer 3000
Date:
September 24 2014
Langue:
English
Plus de détails

The diffusion barrier technique can be used for any colloidal sample with high conductivity. This application note discusses the application of the diffusion barrier technique to high conductivity samples through the measurement of various liposome samples. The method minimizes Joule heating, electrode blackening, sample degradation and electrode polarization.

Produits:
Gamme Zetasizer Nano
Date:
September 30 2014
Langue:
English
Plus de détails

GPC/SEC can be used to characterize commodity or bulk manufactured polymers. Here we describe how the use of formic acid instead of HFIP as the dissolution solvent and/or mobile phase can lead to improvements in both cost per analysis and health and safety..

Produits:
Viscotek 270max
Date:
November 10 2014
Langue:
English
Plus de détails

Use DSC to select antibody with lowest propensity to aggregate. An important consideration during the engineering process of an antibody is both the inherent conformational stability of the antibody as well as long-term stability. Understanding these stability parameters and what trends they follow will be critical throughout the biotherapeutic development. Differential scanning calorimetry (DSC) is a potent tool in probing these qualities. As a stability indicating assay, DSC provides insights for the selection of stable protein construct candidates. In the case of multi-domain proteins, DSC uniquely allows the investigation of the stability of individual domains from multi-domain proteins like antibodies and Fc-conjugated proteins. In this application note, we compare stability data predicted by DSC of different engineered antibodies with SEC-HPLC data from accelerated stability studies. For the engineered proteins studied, there is a correlation between decreased thermostabilty based on DSC data, and greater aggregation formation during accelerated stability studies. This study demonstrates how DSC can be a useful tool in stability screening of engineered proteins..

Produits:
Gamme DSC MicroCal
Date:
November 17 2014
Langue:
English
Plus de détails

See how DSC can be used to assess the effects of polyol excipients on antibodies. Differential scanning calorimetry was used to monitor polyol-induced increases in thermal stability across seven monoclonal antibodies. The increases in thermal stability were measured as a function of polyol concentration and orientation of hydroxyl groups. It was found that increases in thermal stability were linear with respect to alcohol concentration. Further, the increase in thermal stability was dependant on the transition temperature; antibodies with lower transition temperatures exhibited a greater increase due to the addition of polyols than antibodies with a higher transition temperature..

Plus de détails

See how to use ITC to modulate Protein Protein interactions in the drug discovery process .

Produits:
Gamme ITC MicroCal
Date:
November 21 2014
Langue:
English
Plus de détails

Analysis of pollen samples on the Morphologi G3 allows them to be automatically characterized in terms of both particle size and shape, aiding the distinction of different pollen types during the development and testing of immunotherapy or diagnostic products. The system helps to monitor the purity of the pollen samples through identification of foreign particles such as spores and undesirable pollen types..

Produits:
Morphologi G3
Date:
December 11 2014
Langue:
English
Plus de détails

This application note shows how rheology and particle size analysis can be used to characterize the properties of HA dermal fillers.

Produits:
Gamme Mastersizer
Date:
January 29 2015
Langue:
English
Plus de détails

A variety of aqueous (water-soluble) cellulose derivatives were characterized using the OMNISEC triple detection GPC/SEC system which revealed subtle, yet distinct differences between them. The differences described in this application note could be used in the pharmaceutical industry to correlate their. molecular properties with performance..

Produits:
Système OMNISEC
Date:
February 3 2015
Langue:
English
Plus de détails

Nanoparticles can be difficult to produce, and are often synthesized in small quantities and dispersed in expensive solvents. The Hydro SV is allows us to measure the particle size distribution samples dispersed in 6-7ml of dispersant, and is therefore ideally suited to the measurement of nanoparticles by laser diffraction. This application note discusses the measurement of two nano-sized pigment samples using the Mastersizer 3000 and Hydro SV, highlighting the capability of the technique in resolving small differences in the particle size of the samples..

Produits:
Mastersizer 3000
Date:
February 4 2015
Langue:
English
Plus de détails

The non-linear viscoelastic behavior of a non-Newtonian material can be determined by measuring the normal force as a function of shear rate using a cone-plate measuring system. The first normal stress difference and first normal stress coefficient which are equivalent to the shear stress and shear viscosity respectively can also be calculated. In this application note we show how such measurements can be made on a rotational rheometer using a surfactant structured bodywash as an example..

Produits:
Gamme Kinexus
Date:
April 13 2015
Langue:
English
Plus de détails

This note discusses a simple rheological test for assessing product stability during transportation.

Produits:
Gamme Kinexus
Date:
April 16 2015
Langue:
English
Plus de détails

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