Therapeutic area expertise

CLS-logo.png From bench-to-bedside, Concept Life Sciences has extensive experience in providing immunology, oncology and neuroscience CRO services to clients discovering and developing treatments for translational research.

As immunology and neuroscience experts, we work with clients to discover new targets and develop treatments for cancer, autoimmune diseases such as multiple sclerosis, liver fibrosis and neurodegenerative diseases.

Collaborative and tailored programs of work to our clients' requirements

Concept Life Sciences applies knowledge and data from fundamental biology, pre-clinical research and clinical trials to ensure our clients’ discovery pipelines address critical, unmet needs.

We work collaboratively and tailor our programs of work to our clients’ requirements, whether that’s customizing our assays to suit target pathways, or designing novel assays.

Our state-of-the-art facilities feature the latest laboratory equipment and cutting-edge technology, such as the IncuCyte® Live Cell Analysis System for visualization and quantification of cell behavior over time and Cytiva’s Biacore 8K and T200 SPR Systems, allowing us to deliver high throughput, quality binding data when screening and characterizing small molecules and biologics, enhancing our biophysical capabilities. Our specialist histology facilities include the Akoya Biosciences® Vectra® Polaris™ Automated Quantitative Pathology Imaging System, capable of multispectral imaging of up to nine markers on one section (9-plex), and we also have access to further specialist equipment (e.g. the NanoString nCounter® Analysis System) through our close academic links.

Our services include designing custom in vitro immune cell-based assays for biomarker discovery, target expression and MOA (mechanism of action) studies.

Cancer services

A hallmark of cancer is its characteristic immunosuppressive immune environment.

We can design specialized assays and programs of work to understand immune function in the tumor microenvironment and how this might be manipulated therapeutically by either antibodies, small molecules or combinations of these. Assays are validated with benchmark controls.

  • Human Mixed Lymphocyte Reactions (MLRs)
  • Exhausted CD4+ T cell Assay
  • Suppression Assays
  • Killing Assay
  • Human Tumour Ex Vivo Systems

Multiple sclerosis services

We have world-leading expertise in research into multiple sclerosis (MS), a disease that requires understanding of immunology, inflammation and neuroscience.

We can provide end-to-end support for MS drug discovery. We offer a suite of in vitro assays for clients seeking to reduce disease progression in MS by improving remyelination efficiency. These include an Oligodendrocyte Precursor Cell (OPC) culture assay to assess the effects of a test substance on differentiation and cell survival.

Following compound screening in our OPC assay, your lead compound can be progressed to our Central Nervous System (CNS) slice model to assess functional remyelination efficiency following toxin-induced demyelination. This model is a powerful screening tool for potential translational tool linking in vitro assays and in vivo studies.

Our range of in vivo MS services allow lead compound assessment in models such as the EAE, cuprizone and LPC MS models.

Autoimmune disease services

We offer CRO services to biotech and pharmaceutical companies developing treatments for a range of autoimmune diseases.

We can tailor immunology screening programs to discover the mechanisms of action (MOA) of your drug candidate for treating autoimmune disease. Such programs often involve a phenotypic screen in which specific cell types (e.g. T cells) are studied in the presence of the test compound(s).

Beyond our in vitro expertise, we offer novel, biologically relevant in vivo models of autoimmune disease, as well as off-the-shelf models for routine screening.

Liver fibrosis services

Our scientific team has world-leading expertise in liver fibrosis research. Leveraging their know-how, we are developing a suite of in vitro, ex vivo and in vivo assays with customizable end-points to study liver disease e.g. transition assays using primary hepatic stellate cells (HSCs) and precision cut liver slices.

Neurodegeneration services

We are scientific experts in neurodegeneration. We offer specialist discovery research services to clients looking to develop novel therapies for a range of neurodegenerative conditions.

We can tailor and develop neuroprotective screening assays to discover the mechanism of action of your drug candidate, with customized assays targeting neurons themselves and/or the supportive glial cells in isolation or co-culture.

  • Primary CNS assays
  • Organotypic Brain Slice Assays
  • Human CNS iPSC Assays