Assay development is a key step for project initiation in the early phase of drug discovery. Generation of suitable assay tools/ligands for novel targets is usually bespoke which has a high cost and time implication. Often appropriate, target specific tools are not readily accessible, particularly for novel targets. The aim of this project was to design an assay toolbox based on frequently used co-factors and non-specific natural ligands which could be used generically across and within a range of protein families and subfamilies.
