Compounds that are unstable in aqueous media may not be able to be maintained at therapeutically effective concentrations in vivo, and therefore have reduced chances of becoming a successful drug candidate. In dosing solutions, drugs may be prone to chemical degradation which may be caused by a variety of mechanisms: hydrolysis, oxidation, light-catalyzed degradation and others. In the gastrointestinal tract drugs can also be subject to chemical degradation under different conditions. It is therefore important to determine the stability of a compound prior to its administration to animals for pharmacokinetic evaluation. Stability testing in buffer solutions at room temperature or 37 ºC at acidic, neutral and basic pH's in early drug discovery allows timely identification of potentially weak candidates.
Compounds that are unstable in aqueous media may not be able to be maintained at therapeutically effective concentrations in vivo, and therefore have reduced chances of becoming a successful drug candidate. In dosing solutions, drugs may be prone to chemical degradation which may be caused by a variety of mechanisms: hydrolysis, oxidation, light-catalyzed degradation and others. In the gastrointestinal tract drugs can also be subject to chemical degradation under different conditions. It is therefore important to determine the stability of a compound prior to its administration to animals for pharmacokinetic evaluation. Stability testing in buffer solutions at room temperature or 37 ºC at acidic, neutral and basic pH's in early drug discovery allows timely identification of potentially weak candidates.
Deliverable: % test compound remaining at each time-point.
