Discovery chemistry

Standing on the precipice of the next ground-breaking discovery

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Few fields are as exciting as discovery chemistry. The most effective cancer therapies and ground-breaking antiviral treatments have recently emerged from the discovery chemist’s electronic laboratory notebook. 

Take advantage of the latest analytical techniques and experiment with us at the edge of possibility to cure the uncurable and treat the untreatable.

Our team of forward-thinking, lightbulb-moment-creating and boundary-pushing scientists bring the latest techniques and state-of-the-art equipment to your drug discovery process. 

Are you ready to explore the frontiers of the new chemical space?

The challenge 

When you’re working at the front-line of drug innovation it can be difficult to access the right knowledge, technology and support. As the regulatory landscape morphs to accommodate new treatment modalities, compliance becomes a moving target and it’s hard to put the right people, analysis and data together to guarantee success.

The solution  

Our job is to be part of your journey to drug discovery, guiding our clients to IP generation, patent creation and publication. We believe in talking scientist-to-scientist, with dedicated points of contact and direct access to the right tools, techniques and expertise to accelerate drugs from discovery to clinic. 

See how we worked with one client on a challenging synthesis project here: Artios leading the way in novel targets for DNA damage response.

Find our full range of discovery chemistry services:

Beyond small molecules

We have a proven track record in progressing small molecule drug discovery programs. But that’s not all we do. Our experienced scientists use the full depth and breadth of their chemistry knowledge, along with advanced analytical instrumentation and AI techniques, to discover and progress new drug modalities, including:  

  • ADC synthesis
    Using cutting edge bioconjugation technology

  • Fragment-based drug design
    With our library of ultra-small (8-16 heavy atoms) fragments we explore the edges of the lean and tractable start points for drug discovery

  • Nucleotide and nucleoside discovery
    We partner with some of the leading developers to deliver published and presented work, using the latest synthesis, purification, characterization and scale-up production methods

  • PROTAC discovery and synthesis
    Combining the benefits of small molecule drugs with gene-based knockdown 

Watch our webinar to learn how we can accelerate the progress of your antibody-drug conjugates (ADCs) projects.

From process research and development to production

When you’re ready to take drug discovery into the development stages, we’re ready to get you from optimization to GMP manufacturing. 

Discover more about our process research and development and GMP manufacturing services.

Process research and development and pre-clinical API manufacture

Concept Life Sciences Process R&D team takes pride in developing scalab...

Our latest published work in discovery chemistry

Regioselective Amidomethylation of 4-Chloro-3-fluoropyridine by Metalation and Minisci-Type Reactions
Nikolaos Papaioannou, M. Jonathan Fray, Andreas Rennhack, Thomas J. Sanderson, and Jamie E. Stokes J. Org. Chem. 2020, 85, 12067-12079

Read the article

Novel C-7 carbon substituted fourth generation fluoroquinolones targeting N. Gonorrhoeae infections
Ralph Kirk, Mark Betson, Matilda Bingham, Paul Doyle, Rebecca Harvey, Anthony Huxley, John Moat, Thomas Pesnot, Michael Tait, Sebastian Hallworth, Gary Nelson, Bioorg. Med. Chem. Lett., 2020, 30, 127428  

Read the article

Ready to take the drug discovery journey with us?

Join us for a short walkthrough of our pharmaceutical discovery and development site in Sandwich, UK. Meet our brilliant scientists as they introduce you to our state-of-the-art facilities, including our MHRA-audited GMP Manufacturing suite, and explain how our capabilities and expertise can accelerate your drug discovery workflow.