Beyond small molecules
We have a proven track record in progressing small molecule drug discovery programs. But that’s not all we do. Our experienced scientists use the full depth and breadth of their chemistry knowledge, along with advanced analytical instrumentation and AI techniques, to discover and progress new drug modalities, including:
- ADC synthesis
Using cutting edge bioconjugation technology
- Fragment-based drug design
With our library of ultra-small (8-16 heavy atoms) fragments we explore the edges of the lean and tractable start points for drug discovery
- Nucleotide and nucleoside discovery
We partner with some of the leading developers to deliver published and presented work, using the latest synthesis, purification, characterization and scale-up production methods
- PROTAC discovery and synthesis
Combining the benefits of small molecule drugs with gene-based knockdown
Watch our webinar to learn how we can accelerate the progress of your antibody-drug conjugates (ADCs) projects.
From process research and development to production
When you’re ready to take drug discovery into the development stages, we’re ready to get you from optimization to GMP manufacturing.
Discover more about our process research and development and GMP manufacturing services.
Our latest published work in discovery chemistry
Regioselective Amidomethylation of 4-Chloro-3-fluoropyridine by Metalation and Minisci-Type Reactions
Nikolaos Papaioannou, M. Jonathan Fray, Andreas Rennhack, Thomas J. Sanderson, and Jamie E. Stokes J. Org. Chem. 2020, 85, 12067-12079
Novel C-7 carbon substituted fourth generation fluoroquinolones targeting N. Gonorrhoeae infections
Ralph Kirk, Mark Betson, Matilda Bingham, Paul Doyle, Rebecca Harvey, Anthony Huxley, John Moat, Thomas Pesnot, Michael Tait, Sebastian Hallworth, Gary Nelson, Bioorg. Med. Chem. Lett., 2020, 30, 127428
Ready to take the drug discovery journey with us?
Join us for a short walkthrough of our pharmaceutical discovery and development site in Sandwich, UK. Meet our brilliant scientists as they introduce you to our state-of-the-art facilities, including our MHRA-audited GMP Manufacturing suite, and explain how our capabilities and expertise can accelerate your drug discovery workflow.
Contact us and let’s discuss your plans.