Knowledge Center

GCI is ideally suited for fragment-based drug discovery due to inherent sensitivity of the detection principle, and the ability to capture fast transitions. Here we show a collection of challenging target classes across a variety of fragment-based drug discovery campaigns where GCI was used to screen fragment libraries (~ 1100 compounds). Hits were picked based on statistical errors and kinetic ...

Focusing efforts on compounds that have the best chance of success delivers significant cost and time savings and ensures that safety and efficacy are integrated from the outset. Identifying the compounds to discard is nearly as important as choosing the ones to progress. We engage with our clients to design a purposeful screening cascade and the most appropriate study formats tailored to ...

Computer aided drug design (CADD) is at the heart of drug discovery and its application to the Design Make Test and Analyze cycle is revolutionizing the industry. CADD not only helps formulate scientific hypotheses and rationalize data, but it also increases research efficiency by focussing laboratory efforts on compounds with the best pharmaceutical potential. Our computational chemists ...

waveRAPID (Repeated Analyte Pulses of Increasing Dulation) is a novel, innovative way of measuring binding kinetics. It works by injecting the sample at a single concentration but in six pulses of increasing duration-> full kinetics can be derived from a single well. Find out more about waveRAPID in this poster! Login or register for free to download.

The Creoptix WAVEsystem: High-throughput, automated, clog-free, label-free kinetics. Get superior affinity and kinetic data, even for the most challenging samples. Find out more about our solution for binding kinetics in this poster! Login or register for free to download.

With the size of commercial libraries now reaching several billions of compounds, screening vast chemical spaces is becoming an attainable prospect. Yet, current screening strategies are unsuitable for such large compound collections. Hence, new technologies need developing to maximise this chemical space and in turn improve our chances of identifying high-quality hits during virtual screening ...

WEE1 and DNA damageWEE1 regulates the G2/M cell cycle checkpoint via phosphorylation of CDK1 at Tyr15, which inhibits CDK1/cyclin B kinase activity. Inhibition of WEE1 overrides DNA damage-induced cell cycle arrest in cells with a dysfunctional G1 checkpoint and drives TP53 mutant cancer cells into mitotic catastrophe. It is therefore an attractive target for enhancing the effects of chemotherapeutic ...

The particle size distribution of particulate systems in the sub-micron and micron range can be measured using the principle of laser diffraction. Samples are tested as either wet or dry dispersions. The exact methodology used to test a sample is specific to both the sample type and instrument setup. Phase-appropriate method development must be performed to ensure subsequently generated data ...

Conventional label-based bioassays can be effective but they come with issues that can skew results. Let us show you how label-free quantification overcomes them. Find out more about how the WAVEsystem can help overcome the challenges you’re facing with conventional label-based bioassays. Login or register for free to download.

While conventional bioassays can be effective, they come with many challenges that can skew results. Here, we highlight the alternatives to label-based bioassays. Whatever your bioassay goals there’s a label-free quantification technology to help you reach them. Find out about the benefits of each label-free technology and how the WAVEsystem can help overcome the challenges you’re facing ...