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Technical Note

31 May 2023 | English

Method Guidance for Morphologi 4-ID Spectrometer Varieties

IntroductionBuilding on customer feedback, in 2020 a new Raman spectrometer was introduced for the Morphologi 4-ID (M4-ID) system. This new spectrometer provides signal-to-noise improvements, enabling Morphologically-Directed Raman spectroscopy (MDRS)measurement times to be shortened, and improving performance for weak scatter applications. This technical note providesguidance on methodtransfer ...

Products:
Morphologi 4-ID
Technology:
Dynamic image analysis, Morphologically Directed Raman Spectroscopy (MDRS), Static image analysis
Method Guidance for Morphologi 4-ID Spectrometer Varieties
Technical Note

15 September 2022 | English

Zeta potential method development

Introduction Zeta potential is an important parameter in understanding the electrostatic repulsive forces present in a colloidal dispersion or a molecular solution [1-5]. The magnitude of the zeta potential value can provide valuable insight into the potential stability of a colloidal system [6,7]. The technique of electrophoretic light scattering is commonly used to measure zeta potential ...

Products:
Zetasizer Advance Range
Technology:
Dynamic Light Scattering
Zeta potential method development
Technical Note

17 May 2021 | English

Using your MicroCal Automated PEAQ-DSC in a BSL-2 laboratory

Are you studying viruses, toxins, infectious agents, pathogens or infectious organisms which pose a moderate hazard to humans or the environment? Are you using differential scanning calorimetry (DSC) for characterization? If you answered YES, you likely have your instrument in a Biosafety Level 2 (BSL-2) lab. This means your DSC needs to be safely decontaminated after use.

Products:
MicroCal PEAQ-DSC Automated, MicroCal PEAQ-DSC
Technology:
Differential Scanning Calorimetry (DSC)
Measurement type:
Particle shape, Particle size
Using your MicroCal Automated PEAQ-DSC in a BSL-2 laboratory
Technical Note

13 April 2021 | English

Zetasizer terminology

The Zetasizer ZS Xplorer software is a powerful tool for size and zeta potential measurements. There are several ways for you to customize your workspace and tables in the software with an abundance of parameters to choose from. Understanding the meaning behind all the terms enables you to appreciate both the hardware and software’s versatility. Furthermore, having a glossary of these terms ...

Products:
Zetasizer range, Zetasizer AT, Zetasizer WT, Zetasizer Lab, Zetasizer Pro, Zetasizer Ultra, Zetasizer Advance Range
Technology:
X-ray Fluorescence (XRF)
Measurement type:
Zeta potential, Particle size
Zetasizer terminology
Technical Note

12 April 2021 | English

Shedding light on Sybody®candidates binding onto Sars-CoV-2 spike RBD

In this technical note, we show how the Creoptix WAVE can be used to understand the binding dynamics of Sybody® candidates to the receptor binding domain (RBD) of SARS-CoV-2, both provided by Linkster Therapeutics AG and the University of Zürich. With high sensitivity and robust microfluidics, the Creoptix WAVE is suitable for competition assays, confirming and enriching ELISA data. By providing ...

Products:
Creoptix WAVE
Technology:
Microfluidics
Industry:
Biologics, Pharmaceutical
Shedding light on Sybody®candidates binding onto Sars-CoV-2 spike RBD
Technical Note

09 March 2021 | English

Introducing Extended Size Range analysis for Zetasizer Advance

Whilst dynamic light scattering (DLS) is a ubiquitous tool for the characterization of nanomaterials, there may be cases where we want to also know about larger material that might also be present within the sample. Here we will introduce a new analysis model to help characterize particles at sizes not typically measurable via DLS with some examples of the benefits and limitations of this ...

Products:
Zetasizer Advance Range
Technology:
Light Scattering, Dynamic Light Scattering
Measurement type:
Particle size, Particle concentration
Introducing Extended Size Range analysis for Zetasizer Advance
Technical Note

08 February 2021 | English

Binding kinetics of a GPCR

In this technical note, we show how the Creoptix WAVE can be used to measure the interaction of a peptide ligand agonist (NTA11) with a thermostabilized variant of the neurotensin receptor 1 (NTSR1) at highest resolution.

Products:
Creoptix WAVE
Technology:
Microfluidics
Industry:
Biologics, Pharmaceutical
Binding kinetics of a GPCR
Technical Note

04 January 2021 | English

Highly sensitive analysis at low immobilization levels, without mass transport limitation

In this technical note, we show the remarkable sensitivity of the Creoptix WAVE. Thanks to the expanded sensing field over which the Grating-Coupled Interferometry (GCI) technology measures, high resolution kinetic determination at even very low responses is possible, potentially reducing material costs significantly.

Products:
Creoptix WAVE
Technology:
Grating-coupled interferometry (GCI)
Industry:
Biologics
Highly sensitive analysis at low immobilization levels, without mass transport limitation