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Introduction Zeta potential is an important parameter in understanding the electrostatic repulsive forces present in a colloidal dispersion or a molecular solution [1-5]. The magnitude of the zeta potential value can provide valuable insight into the potential stability of a colloidal system [6,7]. The technique of electrophoretic light scattering is commonly used to measure zeta potential ...

This document highlights the requirements of 21 CFR part 11, the functionality in the standard operating software and the extra feature provided by the 21 CFR part 11 optional software package (CPS0032) which implements digital signatures for the Zetasizer Nano instrument.

This document provides details on how to use the 21 CFR part 11 features provided for the Zetasizer Nano software.

Are you studying viruses, toxins, infectious agents, pathogens or infectious organisms which pose a moderate hazard to humans or the environment? Are you using differential scanning calorimetry (DSC) for characterization? If you answered YES, you likely have your instrument in a Biosafety Level 2 (BSL-2) lab. This means your DSC needs to be safely decontaminated after use.

The Zetasizer ZS Xplorer software is a powerful tool for size and zeta potential measurements. There are several ways for you to customize your workspace and tables in the software with an abundance of parameters to choose from. Understanding the meaning behind all the terms enables you to appreciate both the hardware and software’s versatility. Furthermore, having a glossary of these terms ...

In this technical note, we show how the Creoptix WAVE can be used to understand the binding dynamics of Sybody® candidates to the receptor binding domain (RBD) of SARS-CoV-2, both provided by Linkster Therapeutics AG and the University of Zürich. With high sensitivity and robust microfluidics, the Creoptix WAVE is suitable for competition assays, confirming and enriching ELISA data. By providing ...

Whilst dynamic light scattering (DLS) is a ubiquitous tool for the characterization of nanomaterials, there may be cases where we want to also know about larger material that might also be present within the sample. Here we will introduce a new analysis model to help characterize particles at sizes not typically measurable via DLS with some examples of the benefits and limitations of this ...

In this technical note, we show how the Creoptix WAVE can be used to measure the interaction of a peptide ligand agonist (NTA11) with a thermostabilized variant of the neurotensin receptor 1 (NTSR1) at highest resolution.

In this technical note, we show the remarkable sensitivity of the Creoptix WAVE. Thanks to the expanded sensing field over which the Grating-Coupled Interferometry (GCI) technology measures, high resolution kinetic determination at even very low responses is possible, potentially reducing material costs significantly.

In this technical note, we show how the Creoptix WAVE system can be used to accurately determine kinetics in serum. Thanks to a no-clog microfluidic design, kinetic studies can be performed under conditions that mimic the native environment as closely as possible, enabling the translation of these results to the clinic.