Identifying critical quality attributes of rAAV samples

The delivery vectors used in gene therapy can be viral, non-viral and engineered vectors. In this work, we will focus on recombinant adeno associated viruses (rAAV). 

In this application note rapid, accurate, and robust quantitative measurements of viral titer and full capsid content for AAV samples will be described. This study will demonstrate the capabilities of OMNISEC and Zetasizer Ultra for analysis of rAAV5 samples at different levels of genome loading and sample heterogeneity.

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