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Nota de Aplicação

23 March 2023 | English

Using transmission XRD in Aeris to measure the crystalline to amorphous ratio in polymers

IntroductionPolymer solids can have a range of mechanical properties, at one extreme they can be very soft and elastic and at the other they can be immensely strong and rigid. Their mechanical properties can change with external conditions such as temperature and pressure. They can be used for a large range of applications from protective coatings to containers and building materials. The ...

Produtos:
Aeris range
Tecnologia:
X-ray Diffraction (XRD)
Using transmission XRD in Aeris to measure the crystalline to amorphous ratio in polymers
Nota de Aplicação

15 February 2023 | English

Enhancing the Particle Size Analysis of Graphite Powders

Global demand for graphite is soaring, driven by the clean energy transition to electric cars and battery energy storage systems, as graphite is used to make lithium-ion battery anodes. The properties that make it a great anode material also lends itself to many other innovative areas of research, such as specialist coatings and inks. For a given application, the particle size and particle ...

Produtos:
Mastersizer 3000
Tecnologia:
Análise de imagem, Difração laser
Tipo de medição:
Forma da partícula, Tamanho da partícula
Enhancing the Particle Size Analysis of Graphite Powders
Nota de Aplicação

14 February 2023 | English

Strategies for improving protein therapeutic half-life using multi-detection SEC

In the field of protein therapeutics, a protein-polymer conjugation strategy can improve the protein’s clinical potential by overcoming some of the challenges, such as physiochemical instability, immunogenicity and suboptimal circulation half-life.[1][2] This strategy is the covalent modification of a therapeutic protein with a polymer of biological or synthetic origin. A commonly used polymer ...

Produtos:
Sistema OMNISEC
Tecnologia:
Cromatografia por Exclusão de Tamanho (SEC), Cromatografia de permeação em gel
Setor:
Farmacêutico, Biológicos
Strategies for improving protein therapeutic half-life using multi-detection SEC
Nota de Aplicação

09 February 2023 | English

Dynamic Light Scattering method development using the Zetasizer Advance Series

This technical note discusses DLS method development with the Zetasizer Advance series and highlighted the various factors that need to be considered. These include cell selection, instrument verification, sample preparation, measurement set up and results analysis.

Produtos:
Zetasizer Advance Range, Zetasizer Lab, Zetasizer Pro, Zetasizer Ultra
Tecnologia:
Espalhamento de luz, Espalhamento de luz dinâmico
Tipo de medição:
Tamanho da partícula
Dynamic Light Scattering method development using the Zetasizer Advance Series
Nota de Aplicação

31 January 2023 | English

Multi-method benchtop analyses to gain novel insight into structure and internal stability of lipid nanoparticles for mRNA delivery

The spectacular success of the Covid-19 vaccines has brought to global attention the potential of mRNA as medicines. It has also helped emphasize for the broader public that there are other types of RNA with a huge therapeutic potential, such as short interfering RNA (siRNA). Although they share the fundamental structure —they are both polymers of ribonucleic acids⁠—there are some notable ...

Produtos:
Linha MicroCal DSC, Zetasizer Ultra, Linha MicroCal ITC, MicroCal PEAQ-DSC
Tecnologia:
Calorimetria de varredura diferencial (DSC), Calorimetria de titulação isotérmica (ITC)
Multi-method benchtop analyses to gain novel insight into structure and internal stability of lipid nanoparticles for mRNA delivery
Nota de Aplicação

25 January 2023 | English

Quality control: Graphitization degree and orientation index in graphite anode materials

Modern batteries, like Li-ion, have revolutionized our day-to-day life – from enabling smart mobile devices to pollution-free electric cars and intelligent power-management solutions. Batteries also hold the potential to be economical solutions for mass energy storage, complementing renewable energy resources for power grid applications. Irrespective of the cathode chemistry, which can be ...

Produtos:
Aeris range, Empyrean range
Tecnologia:
X-ray Diffraction (XRD)
Setor:
Energia/bateria
Quality control: Graphitization degree and orientation index in graphite anode materials
Nota de Aplicação

08 December 2022 | English

Lipid nanoparticle characterization: differential scanning calorimetry

In this application note field application scientist, Dr Agatha Rosenthal discusses how the MicroCal PEAQ DSC can be used to analyze the thermal stability of mRNA-LNP formulations.

Produtos:
Linha MicroCal DSC
Tecnologia:
Microcalorimetria
Setor:
Caracterização de partículas, Desenvolvimento de fármacos, Fabricação de produtos farmacêuticos, Nanopartículas, Desenvolvimento de bioformulações, Desenvolvimento de processos
Lipid nanoparticle characterization: differential scanning calorimetry
Nota de Aplicação

08 December 2022 | English

Lipid nanoparticle characterization: electrophoretic light scattering

In this application note, Field Application Scientist Dr Jonathan Mehtala describes how pharmaceutical scientists are using electrophoretic light scattering (ELS) to characterize lipid nanoparticles (LNPs) and why you should be using it. Reflecting on a recent publication that investigates the characterization of viral and non-viral vectors using multiple Malvern Panalytical technologies, ...

Produtos:
Zetasizer Advance Range
Tecnologia:
Espalhamento de luz
Setor:
Biológicos, Desenvolvimento de fármacos
Lipid nanoparticle characterization: electrophoretic light scattering
Nota de Aplicação

08 December 2022 | English

Lipid nanoparticle characterization: nanoparticle tracking analysis

A recent publication investigates the characterization of viral and non-viral vectors using multiple Malvern Panalytical technologies. This application note takes a close look at how NanoSight NS300 easily can provide a more detailed understanding of a sample’s size distribution and at the same time inform us on the concentration of the different populations in the sample.

Produtos:
Linha NanoSight, Zetasizer Ultra
Tecnologia:
Análise de Rastreamento de Nanopartículas
Setor:
Biológicos, Farmacêutico
Lipid nanoparticle characterization: nanoparticle tracking analysis
Nota de Aplicação

05 November 2022 | English

Non-destructive, small-scale analysis of cultural heritage objects with Empyrean

X-ray diffraction (XRD) is a powerful tool for studying cultural heritage objects. By identifying crystalline pigments, it can determine the materials used, whether alteration or corrosion has taken place, how the objects were made, and their originality. To protect and preserve the artifacts, this analysis must be non-destructive. When working with smaller-sized objects, researchers often ...

Produtos:
Empyrean
Tecnologia:
Micro X-ray Diffraction
Setor:
Acadêmico, Análise Forense, Universidade
Non-destructive, small-scale analysis of cultural heritage objects with Empyrean