Centro de conhecimento

Compound semiconductor functionality is all about the layer structure. But unlike a cake, it’s rare that you wish to slice up your wafer to see what is going on inside. Fortunately, though, in this instance you can turn to metrology technologies, such as X-ray diffractometry (XRD), to generate accurate and precise structural metrology in a non-destructive manner. Here, advanced capabilities ...

Heavy mineral sands are the source of various commodities such as white titanium dioxide pigment and titanium metal. The three case studies in this paper show the value of X-ray diffraction (XRD) and statistical methods such as data clustering for process optimization and quality control during heavy mineral processing. The potential of XRD as an automatable, reliable tool, useful in the ...

Additive manufacturing (or AM) is fast taking off as a way to produce a wide range of components more efficiently, sustainably, and cost-effectively. John Duffy, Sector Marketing Manager for Advanced Materials, shares his views on what the additive manufacturing world looks like today, what it might look like in future, and how Malvern Panalytical helps make that future a reality. Please ...

Battery power is increasingly being recognized as a viable option for sustainable energy storage and electric transportation. Umesh Tiwari, Global Manager for Advanced Materials and an expert in batteries and renewable energies, discusses the current battery landscape, the future of battery technologies, and the solutions Malvern Panalytical can provide. Please login or register for free ...

This article introduces an energy dispersive X-ray fluorescence (EDXRF) spectrometer for on-line elemental analysis in liquid process flows: Malvern Panalytical’s Epsilon Xflow. This technology enables the user to analyze, control and steer liquid-based production processes in real time, thereby optimizing production processes and blending operations. The analytical performance of the on-line ...

Viruses are increasingly used as vectors for delivery of genetic material for gene therapy and vaccine applications. Recombinant adeno-associated viruses (rAAVs) are a class of viral vector that is being investigated intensively in the development of gene therapies. To develop efficient rAAV therapies produced through controlled and economical manufacturing processes, multiple challenges ...

Biophysical screening of compound libraries for the identification of ligands that interact with a protein is efficient, but does typically not reveal if (or how) ligands may interfere with its functional properties. For this a biochemical/functional assay is required. But for proteins whose function is dependent on a conformational change, such assays are typically complex or have low throughput. ...

Narcolepsy type 1 (NT1) is a chronic neurological disorder that impairs the brain’s ability to control sleep-wake cycles. Current therapies are limited to the management of symptoms with modest effectiveness and substantial adverse effects. Agonists of the orexin receptor 2 (OX2R) have shown promise as novel therapeutics that directly target the pathophysiology of the disease. However, identification ...

Reliable measurement of the binding kinetics of low molecular weight analytes to their targets is still a challenging task. Often, the introduction of labels is simply impossible in such measurements, and the application of label-free methods is the only reliable choice. By measuring the binding kinetics of Ni(II) ions to genetically modified flagellin layers, we demonstrate that: (1) Grating-Coupled ...

Cell division is often regulated by extracellular signaling networks to ensure correct patterning during development. In Arabidopsis, the SHORT-ROOT (SHR)/SCARECROW (SCR) transcription factor dimer activates CYCLIND6;1 (CYCD6;1) to drive formative divisions during root ground tissue development. Here, we show plasma-membrane-localized BARELY ANY MERISTEM1/2 (BAM1/2) family receptor kinases ...