Centro de conhecimento

Determination of binding kinetics is an imperative and laborious phase in biological drug discovery. The WAVEsystem, a Creoptix technology, was developed with researchers in mind. Based on the GCI detection principle, it provides outstanding sensitivity, reducing sample consumption and mass transfer hindrances. Combining GCI technology with our no-clog WAVEchips and waveRAPID (a new method ...

GCI is ideally suited for fragment-based drug discovery due to inherent sensitivity of the detection principle, and the ability to capture fast transitions. Here we show a collection of challenging target classes across a variety of fragment-based drug discovery campaigns where GCI was used to screen fragment libraries (~ 1100 compounds). Hits were picked based on statistical errors and kinetic ...

waveRAPID (Repeated Analyte Pulses of Increasing Dulation) is a novel, innovative way of measuring binding kinetics. It works by injecting the sample at a single concentration but in six pulses of increasing duration-> full kinetics can be derived from a single well. Find out more about waveRAPID in this poster! Login or register for free to download.

The Creoptix WAVEsystem: High-throughput, automated, clog-free, label-free kinetics. Get superior affinity and kinetic data, even for the most challenging samples. Find out more about our solution for binding kinetics in this poster! Login or register for free to download.

The particle size distribution of particulate systems in the sub-micron and micron range can be measured using the principle of laser diffraction. Samples are tested as either wet or dry dispersions. The exact methodology used to test a sample is specific to both the sample type and instrument setup. Phase-appropriate method development must be performed to ensure subsequently generated data ...

Conventional label-based bioassays can be effective but they come with issues that can skew results. Let us show you how label-free quantification overcomes them. Find out more about how the WAVEsystem can help overcome the challenges you’re facing with conventional label-based bioassays. Login or register for free to download.

While conventional bioassays can be effective, they come with many challenges that can skew results. Here, we highlight the alternatives to label-based bioassays. Whatever your bioassay goals there’s a label-free quantification technology to help you reach them. Find out about the benefits of each label-free technology and how the WAVEsystem can help overcome the challenges you’re facing ...

The structural complexity of viral vectors and lipid nanoparticles (LNPs) is integral to their function and successful formulation. Particle characterization is becoming increasingly important when such molecules are used as delivery platforms for nucleic acids (mRNA, DNA). During design, product development and process, characterization and quality control of physical and chemical attributes ...

Identifying the relevant analytical methods to characterize adeno-associated viruses (AAVs) helps gene therapy developers determine product stability during formulation development. This provides a strong foundation for robust products and simplified distribution. Scientists from Leukocare and Malvern Panalytical compared the analytical techniques used to study features of viral vectors that ...

Crystalline quality is an important parameter to monitor for ensuring high device yield and performance. Measuring crystalline quality is also important for studying deposition processes for the growth of epitaxial laters. Please login or register to read more.