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Nota técnica

15 September 2022 | English

Zeta potential method development

Introduction Zeta potential is an important parameter in understanding the electrostatic repulsive forces present in a colloidal dispersion or a molecular solution [1-5]. The magnitude of the zeta potential value can provide valuable insight into the potential stability of a colloidal system [6,7]. The technique of electrophoretic light scattering is commonly used to measure zeta potential ...

Produtos:
Zetasizer Advance Range
Tecnologia:
Espalhamento de luz dinâmico
Zeta potential method development
Nota técnica

17 May 2021 | English

Using your MicroCal Automated PEAQ-DSC in a BSL-2 laboratory

Are you studying viruses, toxins, infectious agents, pathogens or infectious organisms which pose a moderate hazard to humans or the environment? Are you using differential scanning calorimetry (DSC) for characterization? If you answered YES, you likely have your instrument in a Biosafety Level 2 (BSL-2) lab. This means your DSC needs to be safely decontaminated after use.

Produtos:
MicroCal PEAQ-DSC Automatizado, MicroCal PEAQ-DSC
Tecnologia:
Calorimetria de varredura diferencial (DSC)
Tipo de medição:
Forma da partícula, Tamanho da partícula
Using your MicroCal Automated PEAQ-DSC in a BSL-2 laboratory
Nota técnica

13 April 2021 | English

Zetasizer terminology

The Zetasizer ZS Xplorer software is a powerful tool for size and zeta potential measurements. There are several ways for you to customize your workspace and tables in the software with an abundance of parameters to choose from. Understanding the meaning behind all the terms enables you to appreciate both the hardware and software’s versatility. Furthermore, having a glossary of these terms ...

Produtos:
Linha Zetasizer, Zetasizer AT, Zetasizer WT, Zetasizer Lab, Zetasizer Pro, Zetasizer Ultra, Zetasizer Advance Range
Tecnologia:
X-ray Fluorescence (XRF)
Tipo de medição:
Potencial Zeta, Tamanho da partícula
Zetasizer terminology
Nota técnica

12 April 2021 | English

Shedding light on Sybody® candidates binding onto Sars-CoV-2 spike RBD

In this technical note, we show how the Creoptix WAVE can be used to understand the binding dynamics of Sybody® candidates to the receptor binding domain (RBD) of SARS-CoV-2, both provided by Linkster Therapeutics AG and the University of Zürich. With high sensitivity and robust microfluidics, the Creoptix WAVE is suitable for competition assays, confirming and enriching ELISA data. By providing ...

Produtos:
Creoptix WAVE
Tecnologia:
Microfluidics
Setor:
Biológicos, Farmacêutico
Shedding light on Sybody® candidates binding onto Sars-CoV-2 spike RBD
Nota técnica

09 March 2021 | English

Introducing Extended Size Range analysis for Zetasizer Advance

Whilst dynamic light scattering (DLS) is a ubiquitous tool for the characterization of nanomaterials, there may be cases where we want to also know about larger material that might also be present within the sample. Here we will introduce a new analysis model to help characterize particles at sizes not typically measurable via DLS with some examples of the benefits and limitations of this ...

Produtos:
Zetasizer Advance Range
Tecnologia:
Espalhamento de luz, Espalhamento de luz dinâmico
Tipo de medição:
Tamanho da partícula, Concentração de Partículas
Introducing Extended Size Range analysis for Zetasizer Advance
Nota técnica

08 February 2021 | English

Binding kinetics of a GPCR

In this technical note, we show how the Creoptix WAVE can be used to measure the interaction of a peptide ligand agonist (NTA11) with a thermostabilized variant of the neurotensin receptor 1 (NTSR1) at highest resolution.

Produtos:
Creoptix WAVE
Tecnologia:
Microfluidics
Setor:
Biológicos, Farmacêutico
Binding kinetics of a GPCR
Nota técnica

04 January 2021 | English

Highly sensitive analysis at low immobilization levels, without mass transport limitation

In this technical note, we show the remarkable sensitivity of the Creoptix WAVE. Thanks to the expanded sensing field over which the Grating-Coupled Interferometry (GCI) technology measures, high resolution kinetic determination at even very low responses is possible, potentially reducing material costs significantly.

Produtos:
Creoptix WAVE
Tecnologia:
Grating-coupled interferometry (GCI)
Setor:
Biológicos
Highly sensitive analysis at low immobilization levels, without mass transport limitation
Nota técnica

24 November 2020 | English

Affinity and kinetics of antibodies in serum

In this technical note, we show how the Creoptix WAVE system can be used to accurately determine kinetics in serum. Thanks to a no-clog microfluidic design, kinetic studies can be performed under conditions that mimic the native environment as closely as possible, enabling the translation of these results to the clinic.

Produtos:
Creoptix WAVE
Tecnologia:
Microfluidics, Grating-coupled interferometry (GCI)
Tipo de medição:
Cinética de ligação, Análises Livre de Marcadores
Affinity and kinetics of antibodies in serum