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Concept Life Sciences celebrates GMP accreditation

Concept Life Sciences, a Malvern Panalytical brand, today announced that it has received certification of compliance with Good Manufacturing Practice (GMP) for the production of active substances at its site in Sandwich, UK. This is the successful outcome of an in-depth Medicines and Healthcare products Regulatory Agency (MHRA) inspection and applies to active pharmaceutical ingredients (APIs) for both human and veterinary use. The certificate demonstrates compliance to safe practices and enables Concept Life Sciences (CLS) to extend its offering to customers, supporting pharmaceutical developers all the way from discovery and early development of candidate molecules to manufacturing drug substances for clinical trials.

Produtos:
Contract Research - Analytical Services
Setor:
Biológicos
Concept Life Sciences celebrates GMP accreditation
Pôster

08 November 2021 | English

Bifunctional degraders of BRPF1 that retain the antiproliferative phenotype

Utilizing our Integrated Drug Discovery Platform consisting of in-house PROTAC synthetic capabilities, ability in PROTAC ADME characterization, and biological screening capabilities in haematological malignancies, we disclose our initial investigations into the role of BRPF1 in Acute Myeloid Leukemia (AML). We have designed a series of BRPF1 PROTACs to test the hypothesis that small-molecule degraders of BRPF1 will have profound antiproliferative effects in AML cell lines that harbor MLL translocations. In addition to their potential as new medicines, PROTACs are a powerful tool in the arsenal of techniques available for target validation.

Produtos:
Contract Research - Bioanalytical and ADMET
Setor:
Farmacêutico
Bifunctional degraders of BRPF1 that retain the antiproliferative phenotype