The efficient operation of granulation processes depends on continuous particle size measurement for:

  • Reliable endpoint detection.
  • Precise granulation profile control.
  • Effective control in continuous processing.
  • Real-time monitoring and control of fines.

Granule size specifications control various performance characteristics including: solubility, bioavailability, and processability. It may be necessary to control unbound fines because of their impact on downstream process performance or to ensure a safe product with acceptable dusting levels.

Granulation is widely applied as a precursor to tableting. Here, granule properties and fine levels must be optimized in order to achieve steady flow through the tablet press, blend homogeneity, effective compression and high quality tablets. Within the pharmaceutical industry, ongoing efforts to move from batch tabletting to continuous manufacturing suites are intensifying the need for improved granulation control.

High shear granulation demands robust, continuous particle size measurement at high solids loadings within a damp, sticky environment. Measurement within a fluidized bed granulator is similarly exacting. The Parsum probe uses the technique of spatial filter velocimetry and is uniquely well-suited to this application. Installed directly into the granulator, it offers proven reliability, producing real-time data, 24/7, without fouling. Probes of different lengths allow measurement from pilot to commercial scale.

Dry compaction is a granulation technology especially well-suited to moisture sensitive materials. Here the associated requirement for dry particle size measurement and the need to measure the transition from fine powder to granule is met by laser diffraction technology.

Whatever the granulation technology, Malvern Panalytical works in partnership with equipment suppliers.

Linha Insitec

Linha Mastersizer

Linha Parsum

Gama do Morphologi

Linha Insitec Linha Mastersizer Linha Parsum Gama do Morphologi

Determinação confiável e consistente do tamanho de partículas em tempo real

Os analisadores de tamanho de partículas mais utilizados no mundo.

Sonda em linha que usa velocimetria de filtro espacial para medição de tamanho de partículas

Imagens automatizadas para caracterização avançada de partículas

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Tipo de medição
Tamanho da partícula
Forma da partícula
Faixa de tamanho das partículas: 0.1µm - 2500µm 0.01µm - 3500µm 50µm - 6000µm 0.5µm - 1000µm
Tecnologia
Difração laser
Velocimetria de filtro espacial
Análise de imagem
Tipo de dispersão
A seco
Spray
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