Binding kinetics on fibrils with label-free, surface-based sensors

Alzheimer’s disease (AD) is the most common form of dementia in older people. This neurodegenerative disorder is characterized by the deposit of toxic b-amyloid plaques (amyloid fibrils) in the brain. b-Amyloid can interact with many intracellular and extracellular molecules, hence the importance of characterizing  both binding affinity and kinetics of these interactions. With high sensitivity and the fastest off-rate resolution, the Creoptix WAVE enables the full kinetic characterization of weak binders on aggregating proteins.

Alzheimer’s disease (AD) is the most common form of dementia in older people. This neurodegenerative disorder is characterized by the deposit of toxic b-amyloid plaques (amyloid fibrils) in the brain. b-Amyloid can interact with many intracellular and extracellular molecules, hence the importance of characterizing  both binding affinity and kinetics of these interactions. With high sensitivity and the fastest off-rate resolution, the Creoptix WAVE enables the full kinetic characterization of weak binders on aggregating proteins.

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