Fecha registrada: March 01 2016

Duration: 46 minutes 04 seconds

Size Exclusion Chromatography (SEC) is a valuable technique for the analysis of macromolecules such as proteins, antibodies, and polysaccharides. Characterization of these materials is essential for many applications, ranging from pharmaceutical/biopharmaceutical manufacturing and development to drug delivery.

As such, SEC has become a fixture in research and QC labs to provide molecular weight, size, shape, purity, and additional information, allowing scientists to exert maximum control over their processes and improve product characteristics and quality.

This webinar will explore the molecular characterization information made available by SEC, and will include some relevant examples to touch upon how this data can assist throughout the drug development pipeline.
Table of contents
1. How Size Exclusion Chromatography can improve processes and quality in biopharmaceutical development
01:17
2. Outline
01:03
3. Life sciences
00:39
4. Life science market sector
01:16
5. Development pipeline
01:08
6. Desired information
01:23
7. Life science sample considerations
01:23
8. Overview of SEC
01:00
9. What Is Chromatography?
01:09
10. Size Exclusion Chromatography
02:13
11. The Separation Process
02:53
12. SEC road map
01:39
13. The Detectors
01:49
14. SEC in life science applications
00:32
15. SEC in life science applications
02:20
16. Why OMNISEC is perfect for life science samples
00:58
17. Sample types suitable for SEC
02:25
18. Life science applications
01:44
19. Proteasome 20S loaded with Cytochrome C
01:58
20. Stretched Protein vs. Globular Protein
01:30
21. Intrinsic Viscosity for Proteins
01:03
22. Antibody Conformational Analysis
01:21
23. Conformational Changes
00:54
24. Conformational Changes
00:39
25. Compositional Analysis
01:07
26. Compositional Analysis
01:11
27. PEGylated Proteins – Compositional Analysis
00:40
28. PEGylated Proteins – Compositional Analysis
01:01
29. Protein Detergent Complex (PDC)
01:37
30. Conclusions
01:05
31. Thank you for your attentionAny questions?
04:16
32. Contact Information
00:51