Fecha registrada: May 25 2017

Duration: 46 minutes 15 seconds

Ophthalmic microemulsion drugs such as Restasis, indicated for dry eye syndrome, are speciality pharmaceuticals, and are considered complex generics because of their route of delivery and localized activity. Complex generics are challenging to produce, particularly so when it comes to proving bioequivalence with the corresponding Reference Listed Drug.

This webinar aims to provide a guide for proper physical characterization of microemulsions, specifically considering some of the issues with the complexity of such formulations.
Table of contents
1. Welcome
00:11
2. Introduction
00:25
3. Complex Generics: Orthogonal Characterization of Microemulsions
00:22
4. Agenda:
00:20
5. Untitled
02:13
6. Complex Generics
00:41
7. Untitled
02:10
8. Untitled
01:01
9. Microemulsions
01:48
10. Microemulsions: Ophthalmics
01:38
11. Ophthalmics: Characterization for Generics - Deformulation and IVBE
01:43
12. Particle size characterization of microemulsions
02:22
13. Microemulsions : Processing
00:05
14. Technique: Dynamic Light Scattering (DLS)
01:16
15. Microemulsions : Processing
00:15
16. Technique: Dynamic Light Scattering (DLS)
00:10
17. Untitled
00:57
18. Untitled
01:08
19. Untitled
00:43
20. Technique: Laser Diffraction (cont.)
01:09
21. Microemulsions for Ophthalmics: Cyclosporine globule size distribution
00:37
22. Measuring Zeta Potential
00:38
23. Measuring Zeta Potential
01:13
24. Measuring Electrophoretic Mobility – Zeta Potential
01:45
25. Ophthalmic microemulsions: Cyclosporine zeta potential
00:51
26. Rheology
03:01
27. Rheology of Microemulsions
01:50
28. Reason for Shear Rate Dependency
01:15
29. More ‘Rheology’ from increase in fluid structure
02:21
30. Ophthalmics: Cyclosporine viscosity vs. shear rate
00:35
31. Reason for Shear Rate Dependency
00:19
32. Ophthalmics: Cyclosporine viscosity vs. shear rate
00:56
33. Ophthalmics: Cyclosporine viscosity vs. shear rate
00:36
34. Dilution effects:
00:57
35. Ophthalmics: modified cellulose (HEC)
00:50
36. Ophthalmics: Cyclosporine viscoelasticity
03:22
37. Summary: Orthogonal Characterization- Microemulsions
00:05
38. Thank You for Your Time
00:08
39. Thank you for your attentionAny questions?
04:02
40. Contact Information
00:17