Titanium dioxide is used in food as a pigment, imparting a white color to food such as powdered donuts, candy and frosting. The International Agency for Research on Cancer (IARC from World Health Organization, WHO) characterized TiO 2 as potentially carcinogenic to human beings. Recent data indicates that TiO2 nanoparticles are cyto and genotoxic against several lineages of cell cultures. They also present high carcinogenic potential in animal models.12,13 It is a controversial subject that extensively attracts the attention of the scientific community. Consequently, the developments of fast and robust methods for TiO2 analytical determinations are welcome.

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