Centro de conocimientos

The particle size distribution of particulate systems in the sub-micron and micron range can be measured using the principle of laser diffraction. Samples are tested as either wet or dry dispersions. The exact methodology used to test a sample is specific to both the sample type and instrument setup. Phase-appropriate method development must be performed to ensure subsequently generated data ...

Conventional label-based bioassays can be effective but they come with issues that can skew results. Let us show you how label-free quantification overcomes them. Find out more about how the WAVEsystem can help overcome the challenges you’re facing with conventional label-based bioassays. Login or register for free to download.

While conventional bioassays can be effective, they come with many challenges that can skew results. Here, we highlight the alternatives to label-based bioassays. Whatever your bioassay goals there’s a label-free quantification technology to help you reach them. Find out about the benefits of each label-free technology and how the WAVEsystem can help overcome the challenges you’re facing ...

Specialized immunohistochemical staining approaches utilized during preclinical and clinical drug discovery research provide valuable insights into the location and positioning of immuno-oncology biomarkers within the tumor and the tumor microenvironment (TME). We deliver powerful multiplex immunohistochemical and RNAscope tissue staining and probing services, using a range of specialized ...

T cells can develop an exhausted phenotype as a result of prolonged antigen stimulation. This exhausted phenotype can occur in both CD4⁺ and CD8⁺ T cells and has been shown to develop within the tumor microenvironment as a potential mechanism by which tumour cells can escape immune surveillance. Here we describe an in vitro human exhausted T cell model that can be used as a valuable tool ...

The structural complexity of viral vectors and lipid nanoparticles (LNPs) is integral to their function and successful formulation. Particle characterization is becoming increasingly important when such molecules are used as delivery platforms for nucleic acids (mRNA, DNA). During design, product development and process, characterization and quality control of physical and chemical attributes ...

Identifying the relevant analytical methods to characterize adeno-associated viruses (AAVs) helps gene therapy developers determine product stability during formulation development. This provides a strong foundation for robust products and simplified distribution. Scientists from Leukocare and Malvern Panalytical compared the analytical techniques used to study features of viral vectors that ...

Crystalline quality is an important parameter to monitor for ensuring high device yield and performance. Measuring crystalline quality is also important for studying deposition processes for the growth of epitaxial laters. Please login or register to read more.

Metal organic frameworks (MOFs) brochure

Regulators are concerned about the potential for environmental chemicals such as agrochemicals and their metabolites to perturb hormone systems. This has led to recommendations for the testing of potential endocrine disrupting chemicals. The Steroidogenesis H295R assay is an in vitro cell model used to investigate compound effects on steroid hormone biosynthesis, specifically 17β-estradiol ...