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Cartel

20 October 2022 | English

Transferring laser diffraction particle size determination methods in a regulated environment

The particle size distribution of particulate systems in the sub-micron and micron range can be measured using the principle of laser diffraction. Samples are tested as either wet or dry dispersions. The exact methodology used to test a sample is specific to both the sample type and instrument setup. Phase-appropriate method development must be performed to ensure subsequently generated data ...

Productos:
Contract Research - Analytical Services
Industria:
Productos farmacéuticos
Transferring laser diffraction particle size determination methods in a regulated environment
Cartel

26 July 2022 | English

The challenges with conventional bioassays (and how to overcome them)

Conventional label-based bioassays can be effective but they come with issues that can skew results. Let us show you how label-free quantification overcomes them. Find out more about how the WAVEsystem can help overcome the challenges you’re facing with conventional label-based bioassays. Login or register for free to download.

Productos:
Creoptix WAVE
Tecnología:
Grating-coupled interferometry (GCI), Microfluidics
Industria:
Productos farmacéuticos, Productos biológicos
The challenges with conventional bioassays (and how to overcome them)
Cartel

26 July 2022 | English

Three alternatives to conventional label-based bio interaction assays

While conventional bioassays can be effective, they come with many challenges that can skew results. Here, we highlight the alternatives to label-based bioassays. Whatever your bioassay goals there’s a label-free quantification technology to help you reach them. Find out about the benefits of each label-free technology and how the WAVEsystem can help overcome the challenges you’re facing ...

Productos:
Creoptix WAVE
Tecnología:
Grating-coupled interferometry (GCI)
Industria:
Productos biológicos, Productos farmacéuticos
Three alternatives to conventional label-based bio interaction assays
Cartel

04 July 2022 | English

Specialist multiplex histology services

Specialized immunohistochemical staining approaches utilized during preclinical and clinical drug discovery research provide valuable insights into the location and positioning of immuno-oncology biomarkers within the tumor and the tumor microenvironment (TME). We deliver powerful multiplex immunohistochemical and RNAscope tissue staining and probing services, using a range of specialized ...

Productos:
Contract Research - Bioanalytical and ADMET, Contract Research - Toxicology
Industria:
Productos biológicos, Productos farmacéuticos
Specialist multiplex histology services
Cartel

21 June 2022 | English

Demonstrating restoration of T cell function in exhausted T cells with IKZF3 small molecule inhibitor, Lenalidomide

T cells can develop an exhausted phenotype as a result of prolonged antigen stimulation. This exhausted phenotype can occur in both CD4⁺ and CD8⁺ T cells and has been shown to develop within the tumor microenvironment as a potential mechanism by which tumour cells can escape immune surveillance. Here we describe an in vitro human exhausted T cell model that can be used as a valuable tool ...

Productos:
Contract Research - Biology
Industria:
Productos biológicos, Productos farmacéuticos
Demonstrating restoration of T cell function in exhausted T cells with IKZF3 small molecule inhibitor, Lenalidomide
Cartel

17 June 2022 | English

Biophysical characterization of viral and lipid-based vectors for vaccines and therapeutics with light scattering techniques

The structural complexity of viral vectors and lipid nanoparticles (LNPs) is integral to their function and successful formulation. Particle characterization is becoming increasingly important when such molecules are used as delivery platforms for nucleic acids (mRNA, DNA). During design, product development and process, characterization and quality control of physical and chemical attributes ...

Productos:
Sistema OMNISEC, Zetasizer Ultra, NanoSight NS300, MicroCal PEAQ-DSC, Rango de equipos MicroCal DSC
Tecnología:
Dispersión de luz, Multi-Angle Dynamic Light Scattering (MADLS), Dispersión de luz dinámica, Dispersión de luz electroforética, Calorimetría de barrido diferencial (DSC), Cromatografía por exclusión de tamaño (SEC)
Industria:
Productos farmacéuticos, Productos biológicos
Biophysical characterization of viral and lipid-based vectors for vaccines and therapeutics with light scattering techniques
Cartel

14 June 2022 | English

Analytical methods to support formulation development for adeno-associated virus (AAV)

Identifying the relevant analytical methods to characterize adeno-associated viruses (AAVs) helps gene therapy developers determine product stability during formulation development. This provides a strong foundation for robust products and simplified distribution. Scientists from Leukocare and Malvern Panalytical compared the analytical techniques used to study features of viral vectors that ...

Tecnología:
Cromatografía por exclusión de tamaño (SEC), Calorimetría de barrido diferencial (DSC), Dispersión de luz estática, Multi-Angle Dynamic Light Scattering (MADLS), Análisis de seguimiento de nanopartículas
Industria:
Productos biológicos
Tipo de medición:
Estabilidad de proteínas
Analytical methods to support formulation development for adeno-associated virus (AAV)
Cartel

10 June 2022 | English

Semiconductor wafers crystalline quality

Crystalline quality is an important parameter to monitor for ensuring high device yield and performance. Measuring crystalline quality is also important for studying deposition processes for the growth of epitaxial laters. Please login or register to read more.

Productos:
X'Pert3 MRD (XL), X'Pert3 range
Tecnología:
X-ray Reflectometry (XRR)
Industria:
Electrónica/Óptica, Semiconductores
Semiconductor wafers crystalline quality
Cartel

23 May 2022 | English

The development of a GLP protocol for the measurement of 17b-estradiol and testosterone in the H295R steroidogenesis assay

Regulators are concerned about the potential for environmental chemicals such as agrochemicals and their metabolites to perturb hormone systems. This has led to recommendations for the testing of potential endocrine disrupting chemicals. The Steroidogenesis H295R assay is an in vitro cell model used to investigate compound effects on steroid hormone biosynthesis, specifically 17β-estradiol ...

Productos:
Contract Research - Biology
Industria:
Productos farmacéuticos, Productos biológicos
The development of a GLP protocol for the measurement of 17b-estradiol and testosterone in the H295R steroidogenesis assay