Ask an Expert! Ambient-temperature porogen-free method for preparation of silica-based macroporous materials

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This work is describing the preparation, characterization and application of silica-based macroporous aggregates composed of silica nanoparticles (NPs) using template-free method at ambient temperature. The proposed method is performed in a liquid phase, where aggregation and functionalization take place using silica-based precursors in a single step process. The used precursor induces interconnection of individual particles, thus increases the strength of the prepared aggregates, and if required, modifies their surface.

The prepared material is ready to use for a broad range of applications including separation of various molecules or enzyme immobilization and does not require any additional functionalization step.

In addition, the final size of the prepared fractal aggregates can be easily controlled by changing the stirring speed and amount of used silica precursor during synthesis. Pore size distribution, porosity and surface area of modified aggregates are easily adjustable by using primary particles of various sizes. As a result, developed porous material is capable to protect long-term enzyme activity and thus demonstrates potential application of the prepared aggregates.


  • Dan Trunov - Assistant professor, University of Chemistry and Technology - Czech Republic
  • Stjepan Prugovecki - Segment Marketing Manager Academia and Research, Malvern Panalytical

Pour en savoir plus

Who should attend?

  • Scientists and researcher interested in porous material.
  • Anyone interested in characterization problem of intrinsic particle properties.
  • Anyone working with the silica materials.

What will you learn?

  • Learn how to perform particle characterization (particle size, pore size distribution).
  • Discover about colloidal stability and potential applications of the prepared aggregates.

Read the paper

Dan Trunov’s paper focuses on the synthesis of silica-based microporous aggregates composed of silica nanoparticles using a template-free method. The results confirm the possibility of tailoring the pore size distribution simply by using primary particles of various sizes. The application of prepared aggregates was demonstrated by the immobilization of urease from Canavalia ensiformis, resulting in high enzyme activity compared with free enzymes.

Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 634, 5 February 2022, 128033 -