SAXS study on the thermostability of a protein in solution

Irreversible aggregation of thyroglobulin at elevated temperature

Temperature-controlled SAXS experiments were done to study the thermal stability and melting behavior of a protein in a dilute solution. Irreversible, nonspecific protein aggregation was observed at elevated temperature.

Here we report a SAXS investigation on the thermostability of a high molecular mass glycoprotein (thyroglobulin) in a buffer solution. 

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