Characterization of proteins and protein self-association (ologomerization) with SEC-MALS

In this poster, a series of proteins and their oligomers were characterized using SEC-MALS with UV and RI detection. The monomer and oligomer molecular weights are measured and compared with those from column calibration and the differences explored. It can be seen that the use of light scattering detectors, significantly improves the accuracy of the molecular weight and thus the confidence in identifying populations as particular oligomers.

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