Centre de connaissances

Du contenu exclusif à portée de main

136 results

Sort search results by or

Page 1 of 14
Livre blanc

05 July 2021 | English

Five compelling reasons to add the Hydro Insight dynamic imaging accessory to your Mastersizer 3000

Scientists, researchers, and quality control managers around the world use laser diffraction for particle size analysis. But, to develop truly high-performance products, you often need deeper insights than those provided by laser diffraction alone. In particular, to understand the influences behind packing, flow, and dissolution rate, you need to understand how particle size and shape affect your materials’ behavior. The Hydro Insight accessory provides these insights by combining Vision Analytical’s dynamic imaging expertise with Malvern Panalaytical’s flow cell and dispersion technology. Sitting alongside our Mastersizer 3000 laser diffraction system, the Hydro Insight provides real-time images of your liquid particle dispersions and individual particles. It provides quantitative data on particle shape as well as a window into your laser diffraction measurement, so you can troubleshoot more easily and develop particle sizing methods more quickly. If you’re still not convinced, we hope this white paper will outline the benefits of adding the Hydro Insight dynamic imaging accessory to your Mastersizer 3000.

Produits:
Mastersizer 3000
Technologie:
Diffraction Laser
Type de mesure:
Taille des particules
Five compelling reasons to add the Hydro Insight dynamic imaging accessory to your Mastersizer 3000
Livre blanc

01 December 2020 | English

Characterization of Catalytic Materials on Laboratory-Based X-Ray Diffraction Platforms

IntroductionCatalytic materials are important for a wide variety of applications from their use in the chemical industry to the utilization in solar energy production to everyday applications such as automotive catalysts. There are three main types of catalysts; heterogeneous catalysts, homogeneous catalysts, and biocatalysts (enzymes), with heterogeneous catalysts the most studied via X-ray diffraction (XRD). Typically, these types of catalysts consist of solid-state materials such as metals, inorganic compounds, and zeolites which increase the rate of reaction due to the surface binding of reactants. Additionally, homogeneous and biocatalysts can be studied to some extent as well. In the analysis of these substances, it is important to examine structure-performance relationships and identify reaction mechanisms (i.e. the elementary reaction steps, intermediates, and active sites) under technologically relevant conditions. To do so requires an in-depth knowledge of the atomic structure on both the short- and long-range scales. X-ray diffraction is a technique that can provide information about the average bulk structure of a material based on the interference pattern resulting from the long-range ordering of scattering centers. Using Bragg’s law, XRD allows for the determination of the spacing between scattering planes (d) by measuring the scattering angle (θ) at a fixed wavelength (λ), as shown in Figure 1. Figure 1: Illustration of Bragg diffraction where two beams with identical wavelength and phase are scattered from two atoms with spacing (d) to give constructive interference (n = 1, 2, 3…) The observed peaks relate to the symmetry and unit cell dimensions of the material and can be used as a fingerprint for phase identification as well as to provide a quantitative analysis of the sample. Furthermore, examination of the peak breadths, low angle scattering, and inverse Fourier transformation of the reciprocal space data can provide information about particle and crystallite size as well as short-range ordering in the material. Much of this information is obtained via X-ray scattering techniques which do not rely on the presence of long-range order and can be utilized to study nano-sized and amorphous materials. Malvern Panalytical’s line of X-ray diffraction instruments can aide in the analysis of catalytic materials by yielding the identification and quantification of both crystalline and amorphous phases as well as providing information about particle and crystallite size, micro strain, thermal stability, and local atomic structure (i.e. short- and intermediate-range order). With the use of non-ambient chambers, catalytic materials can be examined under various operating conditions which can aide in understanding reaction pathways and identifying the presence of intermediate phases. Under these conditions it is possible to monitor processes such as oxidation/reduction reactions that contribute to the activation of catalytic materials. Additionally, many catalysts consist of nano sized materials making information regarding the local structure an important aspect of performance optimization. As XRD only provides information related to the bulk structure of materials, it is often necessary to perform additional methods such as small angle X-ray scattering (SAXS) and pair distribution function (PDF) analysis. These techniques allow for the determination of structural information on the nanometer scale (i.e. 1 – 100 nm) which is a pertinent size range for many catalytic materials. In particular, information such as particle size and shape as well as specific surface area (SSA) can be obtained via SAXS measurements while PDF analysis provides information regarding short-range atomic order (i.e. atomic pair correlations) which can give insight into nanocrystalline and amorphous phases as well as local structure variations. This white paper highlights several techniques that can be performed on Malvern Panalytical’s floor standing and benchtop XRD platforms to assist in the characterization of catalytic materials. With Malvern Panalytical’s Empyrean instrument, which allows for the easy exchange of stages and optics, basic powder X-ray diffraction (PXRD) measurements (i.e. phase identification and quantification) as well as non-ambient, SAXS and PDF experiments can all be performed without the need for re-alignment of the instrument. Additionally, both PXRD and non-ambient measurements can also be performed on the benchtop Aeris instrument which has comparable resolution, scan-times, and peak intensities to the floor standing Empyrean. Data from both instruments can be analyzed via HighScore (Plus) software for phase identification and quantification as well as the analysis of non-ambient and PDF data. Additionally, Malvern Panalytical’s EasySAXS software provides a straightforward method to obtain relevant information from SAXS data. Please login or register for free to read more.

Produits:
PIXcel3D
Technologie:
Lumière diffusée
industrie:
Produits chimiques
Characterization of Catalytic Materials on Laboratory-Based X-Ray Diffraction Platforms
Livre blanc

22 October 2020 | English

10 reasons to trust Mastersizer 3000

Modern industrial processes rely on a growing range of sophisticated technologies to ensure the quality of materials and finished products. The more these systems become embedded, the heavier the reliance on their abilities to perform consistently and to deliver essential data for critical decision-making. And the greater the risk, should they fail to do so. Investing in technology solutions that are tried and trusted helps mitigate that risk, in the knowledge that they embody the accumulated experience and expertise of others and have a track record of dependable practical service. However, they must also align with current needs and have the capacity to accommodate evolving quality requirements. Mastersizer has long been one of the most trusted brands in particle sizing. Upholding this reputation, the industry-leading Mastersizer 3000 laser diffraction particle size analyzer has earned the confidence of thousands of users around the world who routinely rely on it. Please login or register to read more.

Produits:
Mastersizer 3000
Technologie:
Diffraction Laser
Type de mesure:
Taille des particules
10 reasons to trust Mastersizer 3000
Livre blanc

06 July 2020 | English

Reasons to upgrade to Mastersizer 3000 now

Unsupported or ageing technology presents business-critical risks to continuity, productivity and output in today’s fast-moving, high-tech laboratory environments where skills and practices have changed dramatically in recent years. Investing in new technology means weighing up the true costs of inaction versus the benefits of staying ahead and what that means for your business. In April 2022, the long-serving Mastersizer 2000 laser diffraction particle size analyzer reaches the end of its supported life. This system triggered a revolution in enabling laser diffraction particle sizing to become the routine analytical tool the manufacturing industry relies on today. It also paved the way for the next generation Mastersizer 3000, a powerful system whose intelligent automated operation, extended measurement range and small footprint perfectly align it with current laboratory pressures and the need for streamlined workflows. A fully supported upgrade to Mastersizer 3000 - whether from Mastersizer 2000 or from an alternative system or technology - will de-risk and future-proof your processes, and there are compelling reasons to act now. Please login or register to read more.

Produits:
Mastersizer 3000
Reasons to upgrade to Mastersizer 3000 now
Livre blanc

28 May 2020 | English

Using Isothermal Titration Calorimetry to Characterize Enzyme Kinetics

Enzymes are proteins that function as biological catalysts, which play crucial roles in the biochemical processes that occur in living organisms. Understanding how enzymes function, and how to activate or inhibit their activity, is a core research focus for biochemists. Since many drug targets are enzymes, the development of new therapies requires understanding of how the target enzyme binds and catalyzes its natural substrate. Several drugs are therapeutic enzymes, which are injected into the patient to treat genetic disorders characterized by missing or defective enzymes. Enzymes are also important in other industries including food science, biofuels, and detergents. Although enzymes were discovered in the mid-1800s, isolated and purified since the early 20th century, and cloned and expressed in recombinant systems since the 1970s, there is a continued need for efficient and detailed enzyme analysis to exploit the potential of enzyme-driven catalytic reactions. New enzymes are also being discovered. Reliable enzyme kinetics data are crucial to understand and control enzyme effectiveness and create next generation drugs. Isothermal titration calorimetry (ITC) techniques have been successfully applied to study enzyme kinetics and inhibition. ITC is a well-established, versatile technique that is widely used for measuring reaction thermodynamics. In this review, we discuss how ITC generates real-time, enzyme kinetics data, comparable to other enzyme assays. In part 2, we discuss how to perform enzyme kinetics experiments with a MicroCal ITC system. Please login or register to read more

Produits:
Gamme ITC MicroCal
Technologie:
Titration Calorimétrique Isotherme (ITC)
industrie:
Développement de formulations pharmaceutiques
Using Isothermal Titration Calorimetry to Characterize Enzyme Kinetics
Livre blanc

15 April 2020 | English

Optimizing Pharmaceutical Formulations: The Role of Physicochemical Analysis

This eBook explores several ways in which Malvern Panalytical’s technologies and expertise can assist pharmaceutical scientists in their quest to develop high quality, safe and effective products, and accelerate their speed to market.

Produits:
Gamme Mastersizer
industrie:
Développement de formulations pharmaceutiques
Optimizing Pharmaceutical Formulations: The Role of Physicochemical Analysis
Livre blanc

10 March 2020 | English

Understanding and Optimizing Complex Pharmaceutical Formulations

A comprehensive ebook designed to help researchers expand and optimize their understanding of complex pharmaceutical formulation. This ebook was written in collaboration by LabCompare and Malvern Panalytical to assist in the understanding and optimization of complex pharmaceutical formulations including automation of manual QC analysis, in vitro bioequlivalence studies for oral solid dose products and Ophthalmic Microemulsions.

Produits:
Morphologi 4-ID
industrie:
Développement de formulations pharmaceutiques
Understanding and Optimizing Complex Pharmaceutical Formulations
Livre blanc

11 April 2019 | English

Field Characterization of White Micas Using the ASD TerraSpec® Halo

The white micas are a diverse group of common fine-grained phyllosilicate minerals that include the true micas paragonite, muscovite, and phengite, as well as the K-deficient mica, illite. This group often serves as a useful exploration vector as they provide an indicator of geothermal and geochemical conditions at the time of their formation. Using the Al-OH scalar reported by the ASD TerraSpec® Halo mineral identifier it is possible to track geochemical conditions while the Illite Spectral Maturity (ISM) scalar (Doulblier et al. 2010) reported by Halo provides an indicator of thermal maturity. The white micas contained in the mineral library used by the ASD TerraSpec Halo mineral identifier are organized by composition. The true white micas are represented by the potassium white micas muscovite and phengite, and the sodic white mica paragonite. The muscovite-phengite series is characterized by increasing substitution of Mg+2 or Fe+2 and Si+4 for Al+3. The illites are classified similarly. Thus, a shift in mineralogy from muscovite and/ or illite (labeled as K-Illite in the Halo mineral library) to paragonite and/or paragonitic illite (labeled as Na-Illite in the Halo mineral library) is indicative of increasingly sodic conditions. Similarly, a shift in mineralogy to phengite and/or phengitic illite (labeled as Mg-Illite in the Halo mineral library) is usually indicative of increasingly magnesium-rich conditions. The ASD TerraSpec Halo mineral identifier is able to track geothermal gradients both by detecting mineralogy and through the reporting of the ISM scalar. With increasing metamorphic grade, smectites convert to illites, which then covert to muscovite (and other true micas). Within the illites, subtle geothermal trends are easily detected and mapped using the Halo’s ISM scalar which tracks the illite dehydration process as the illite converts to true mica.

Produits:
ASD TerraSpec Halo
Technologie:
Near-infrared Spectroscopy (NIR)
industrie:
Exploitation minière
Field Characterization of White Micas Using the ASD TerraSpec® Halo
Livre blanc

22 November 2018 | English

XRD of gallium nitride and related compounds: strain, composition and layer thickness (booklet)

This book provides an introduction to the X-ray diffraction analysis of key structural parameters in epitaxial GaN layers. Fundamental crystallographic concepts are introduced and related to the specific requirements of the technological structures created for optoelectronic and electronic devices employing GaN and related compounds.

Produits:
X'Pert3 MRD
Technologie:
X-ray Diffraction (XRD)
XRD of gallium nitride and related compounds: strain, composition and layer thickness (booklet)