Liposomes have been widely used as model membranes and in drug delivery, as their basic properties can easily be varied to target desired properties (lipid composition, concentration, water content, media (different buffers, varying ionic strength, pH, etc.) as well as lamellarity (unilamellar, large or small (Large Unilamellar Vesicles, LUVs, and Small Unilamellar Vesicles, SUVs), and multilamellar vesicles, MLVs)). In these studies, one must characterize the pure liposomes as well as their mixtures with other molecules (proteins, peptides, drugs), to ascertain the influence of the added component in the liposome phase behavior.
DSC is a fundamental technique for the characterization of membrane behavior, providing all thermodynamic parameters for temperature-induced transitions. Furthermore, for mixtures of membranes with other components (drugs, proteins, peptides, polymers, etc.) DSC represents a first-line screening method, providing information on the effect(s) of the added components on membrane behavior.
아직 회원가입하지 않으셨습니까?
Sign up for free today. By registering you will have free access to exclusive content including
- Webinars, presentations and videos
- Application notes, technical notes, articles, white papers and software downloads
And in addition you will receive
- Our regular eNews including the latest news, education, events and offers from Malvern Panalytical