Fecha registrada: May 31 2012

Duration: 48 minutes 49 seconds

The techniques of laser diffraction and automated particle imaging support the fast, cost-effective development of nasal spray products, simultaneously providing the data required for regulatory compliance; this webinar examines their appliccation.
Table of contents
1. Laser diffraction and imaging: complementary techniques for nasal spray development
02:09
2. Laser diffraction and imaging: complementary techniques for nasal spray development
00:48
3. Guidance for Industry
01:10
4. In Vitro BA / BE is usually assessed by the following 7 device and formulation tests:
03:27
5. The goal of nasal spray characterisation is to understand how a drug is delivered and absorbed
00:55
6. Laser diffraction droplet size analysis provides a means of assessing product performance in vitro
01:16
7. During the pump actuation, significant changes in droplet size and concentration are observed
03:32
8. Through-life device performance can be monitored through monitoring stable phase changes
01:53
9. The robustness of delivery can also be studied by changing the actuation conditions
01:53
10. One method of improving product stability is to use viscosity-modifying excipients
00:40
11. Changing the Newtonian viscosity of a formulation can significantly affect the atomisation dynamics
01:30
12. Stability and absorption may be enhanced by using a rheology modifier which imparts thixotropy
01:22
13. Using thixotropic formulations may yield improved atomisation at high actuation forces / velocities
01:51
14. Changing the nasal spray pump mechanism may provide a means of improving atomisation
01:43
15. The actuator orifice diameter can also be reduced in order to yield a smaller droplet size
01:14
16. The goal of nasal spray characterisation is to understand how the drug is delivered and absorbed
01:06
17. Automated image analysis provides one method of obtaining information regarding particle form
01:46
18. A range of size and shape descriptors can be obtained to characterise different sample types
01:09
19. Using these shape and size parameters can provide a means of detecting different components
01:38
20. The changes in drug particle size during delivery can then be understood
01:16
21. Sometimes, accurate component classification may not be possible using morphology alone
01:11
22. The combination of image analysis and Raman spectroscopy can improve particle identification
00:42
23. The combination of image analysis and Raman spectroscopy can improve particle identification
00:52
24. Raman spectra can be obtained for individual particles detected using the imaging system
00:57
25. The components in the sample can be classified via spectral matching against reference spectra
01:24
26. The size and shape distributions for each component can then be calculated…
00:40
27. … and particle classification carried out, which may show if contaminants are present
00:45
28. Conclusions
01:04
29. Acknowledgements
01:01
30. Laser diffraction and imaging: complementary techniques for nasal spray development
00:15
31. Contact Information
07:40