Laser diffraction Masterclass 5: Setting particle size specifications

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00:00:00 Laser diffraction masterclass 5: Setting specifications
00:00:51 Masterclass 5: Specification setting
00:01:19 Laser diffraction measurement process
00:02:03 Laser Diffraction Masterclass
00:02:26 Overview
00:03:35 What is a specification?
00:04:52 What properties should be considered?
00:05:39 When should particle size be measured?
00:07:48 How should specifications be justified?
00:08:30 What should specifications be based on?
00:10:53 Understanding the results from a diffraction system
00:13:01 Typical laser diffraction results
00:13:29 Distribution statistics: Median and mode
00:13:50 Distribution statistics: Median and mode
00:14:38 Distribution statistics: Percentiles
00:15:38 Distribution statistics: Percentiles
00:16:16 Distribution statistics: Mean particle sizes
00:16:53 Distribution statistics: Mean particle size
00:18:04 Distribution statistics: Mean particle sizes
00:18:48 Distribution statistics: Sampling requirements
00:18:53 Distribution statistics: Sampling requirements
00:20:00 Definitions of measurement precision
00:21:39 What precision values are reasonable?
00:23:15 Setting a specification: Dissolution dynamics
00:25:08 Controlling the dissolution rate
00:26:04 Controlling the dissolution rate
00:26:48 Tracking changes in particle size
00:28:25 Controlling formulation stability: sedimentation
00:29:23 Controlling suspension rheology
00:29:57 How does particle size affect suspension rheology?
00:30:02 Factors affecting the tableting process
00:30:54 Forces of adhesion as a function of particle size
00:31:38 Specification example: Tablet formulation
00:32:29 Specification example: Tablet formulation
00:33:59 Specification example: Tablet formulation
00:36:21 Linking measurement data and manufacturing specifications
00:37:07 Conclusions
00:38:29 Questions
00:43:07 Thank you
00:43:46 Upcoming webinars
In this webinar we look at the particle size distribution data generated by laser diffraction, and consider how these can be used to generate realistic product specifications.