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Application Notes

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The properties of polymeric excipients can directly affect the clinical efficacy, safety, and quality of a finished pharmaceutical product and are routinely identified as critical quality attributes (CQAs). This article looks at how gel permeation/size exclusion chromatography (GPC/SEC) can be applied to measure characteristics such as molecular weight, distribution, structure, and degree of branching..

Produkte:
OMNISEC System
Datum:
June 9 2017
Sprache:
English
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Products, quality is often defined by a range of functional and sensory attributes, some of which may be easily measured - such as color - and others which may not. Visual or textural appearance and ease of application exemplify properties in this second category. Ultimately these attributes are assessed subjectively via user feedback, but relying on such information to guide formulation is somewhat impractical, particularly in the early stages of product development. Metrics that reliably correlate with product performance are therefore essential.. Rheology adds value in product formulation and benchmarking studies by providing these product performance metrics. The resulting data can be used either to replicate the quality of an existing product, to compare formulations or competitor products, or to develop a specification for a brand new product. Rheological properties such as viscosity, yield stress and viscoelasticity can be used to determine how easy it is to squeeze toothpaste or ointment from its packaging, to spread a body lotion over skin, or the feel of skin cream when the user dips their fingers into the pot. In addition it can also be used to assess and predict product stability and help to resolve process issues. In this article we look specifically at the application of rheological tests to quantify aspects of consumer product performance focusing on which tests are best for which application and the selection of appropriate test conditions..

Produkte:
Kinexus ultra+
Datum:
August 3 2016
Sprache:
English
Mehr Details

Particle size analysis is important in many industries. Knowledge of particle size is important in the food industry because it affects the production and handling of ingredients and the formulation, processing, and quality control of food and beverage products. Particle size affects reactivity, solubility, and flowability of ingredients and the texture, mouthfeel, and processing of products.. Particle size analysis has been applied to a wide variety of ingredients and products, including coffee, sugar, salt, flour, chocolate, milk powder, spices, and flavors. Analytical techniques for measuring particle size range from traditional sieving and sedimentation to use of modern automated imaging and laser-based instruments..

Produkte:
Morphologi G3
Datum:
August 12 2016
Sprache:
English
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A defining feature of polysaccharides, which are used widely as food additives and for certain medical applications, is that they are naturally occurring and consequently prone to inherent variability. In this article we discuss how advanced gel permeation/size exclusion chromatography (GPC/SEC) systems deliver the molecular weight and structural information needed to understand and control the performance of polysaccharides and ensure exemplary quality control. .

Produkte:
OMNISEC System
Datum:
October 17 2016
Sprache:
English
Mehr Details

This note details the requirements of 21 CFR Part 11and describes how the Morphologi software meets these requirements.

Produkte:
Morphologi G3
Datum:
June 17 2014
Sprache:
English
Mehr Details

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