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Applikationsbericht

18 September 2023 | English

Overcoming challenges in LNP vector analysis: key tools, techniques, and considerations

In this eBook, Malvern Panalytical will guide you through the different challenges, technologies and solutions facing LNP vector analysis. This information can help empower everything from vector design through formulation development and manufacturing, enabling more confident decision-making for faster delivery of better medicines to patients in need.

Produkte:
MicroCal DSC Linie, Zetasizer Ultra, Zetasizer Advance Range, NanoSight Pro, OMNISEC System
Technologie:
Dynamische Lichtstreuung, Dynamische Differenzkalorimetrie (DSC), Elektrophoretische Lichtstreuung, Size Exclusion Chromatography (SEC), NTA (Nanoparticle Tracking Analysis), Multi-Angle Dynamic Light Scattering (MADLS)
Industrie:
Biologika, Behörden/Institute, Lehreinrichtungen, Universität, Pharmazie
Overcoming challenges in LNP vector analysis: key tools, techniques, and considerations
Poster

15 September 2023 | English

Kinetic screening using Grating-Coupled Interferometry (GCI)

GCI is ideally suited for fragment-based drug discovery due to inherent sensitivity of the detection principle, and the ability to capture fast transitions. Here we show a collection of challenging target classes across a variety of fragment-based drug discovery campaigns where GCI was used to screen fragment libraries (~ 1100 compounds). Hits were picked based on statistical errors and kinetic ...

Produkte:
Creoptix WAVE
Technologie:
Microfluidics, Grating-coupled interferometry (GCI)
Industrie:
Biologika, Pharmazie
Kinetic screening using Grating-Coupled Interferometry (GCI)
White-Paper

15 September 2023 | English

Next-level flexibility for drug discovery

The interaction between compounds and their drug targets – particularly the binding kinetics – is an essential part of the identification and validation of new therapeutics and small-molecule drugs. But, despite the many technological advances in research and development, many challenges remain in using kinetic analysis for the early stages of drug discovery. In this whitepaper, we aim to ...

Produkte:
Creoptix WAVE
Technologie:
Microfluidics, Grating-coupled interferometry (GCI)
Typ der Messung:
Markierungsfreie Analyse, Association Constant, Dissociation Constant, Bindungsaffinität, Bindungskinetik, Molekulargewicht, Molekülgröße
Next-level flexibility for drug discovery
Technischer Bericht

13 September 2023 | English

NanoSight NS300 Tube Configurations

Since the NS300 has been reclassified as a Class 3R laser product, the aperture in the instrument case must be covered. The NS300 was originally shipped with a bulkhead tubing connector. This was often removed and misplaced. We are now offering a cheaper 3D printed tube slot which is much easier to use. It is recommended that any user who has no bulkhead connector fitted order this replacement ...

Produkte:
NanoSight NS300
Technologie:
NTA (Nanoparticle Tracking Analysis)
NanoSight NS300 Tube Configurations