Discriminating between polymorphs of acetaminophen using Morphologically-Directed Raman Spectroscopy

Polymorphic conversions are an ongoing problem in the pharmaceutical industry. Here we describe the use of Morphologically-Directed Raman Spectroscopy (MDRS®), available on the Morphologi® ID, to distinguish and quantify particles of different polymorphic types of acetaminophen (paracetamol) within a mixture. MDRS is a flexible tool for root cause analysis, product quality and formulation development and is well-suited to identifying even low-level polymorphic contamination.


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