Interactions of Bovine Serum Albumin with Aluminum Polyoxocations

The Zetasizer Nano ZS is shown to measure the size of Aluminium Keggin ions of about 1nm diameter, and the zeta potential of Aluminium ion-BSA complexes. The zeta potential results support electrostatic interactions between the Al ions and BSA. The Zetasizer Nano has been successfully used to determine the size of Al13 and Al30-mers and characterize the size of complexes formed between these aluminum polyoxocations and bovine serum albumin. Measurement of the zeta potentials of Al-BSA mixtures can provide insight into the mechanisms of interaction involved in the formation of polyoxocation-protein complexes.The same interactions probably form the basis of adjuvent properties of alum.


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