Tabletting - a modern approach

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00:00:00 Tabletting - a modern approach
00:02:21 Tablets/tabletting (or is it tableting?)
00:02:53 Overview
00:04:32 Abstract
00:05:12 Aspirin Life Magazine October 22, 1945 page 69
00:06:43 Plagiarism
00:07:12 Advantages of tablets
00:08:15 Advantages of tablets
00:08:44 Disadvantages of tablets
00:09:31 The beginnings of tablets
00:10:33 The beginnings of tablets
00:11:22 The beginnings of tablets Remington Tablet Machine Circa 1875
00:11:57 Stages in Compaction
00:12:48 Plastic Flow or Brittle Fracture?
00:13:44 Plastic Flow or Brittle Fracture?
00:14:55 Lubricants
00:16:50 Ideal properties for a direct compression excipient
00:17:29 Direct compression excipient
00:18:45 Compressibility
00:19:27 Tabletability
00:19:52 Compactibility
00:21:16 Stages in tabletting
00:22:34 Wet granulation - advantages
00:23:18 Wet granulation - disadvantages
00:23:53 Dry/direct compaction
00:24:28 Dry/direct compaction Disadvantages
00:25:37 Factors Influencing Dispersion Rheology
00:26:19 Untitled
00:26:42 Untitled
00:27:37 Untitled
00:28:06 Effect of Particle Shape
00:28:57 Materials
00:29:24 Materials Particle Size
00:30:10 Adhesion force
00:31:18 Materials Particle size distributions
00:32:30 Materials Particle Size Distribution
00:33:02 Where do the materials go after compression?
00:34:43 Malvern: From Particles to Tablets
00:34:55 NIR Chemical Imaging
00:35:37 SynIRgi
00:36:02 Content uniformity
00:36:59 Materials – theory Hersey - 1970
00:37:40 Heckel theory – most useful
00:37:56 Methodology
00:38:51 Particle shape
00:39:37 Other properties
00:39:59 Untitled
00:40:32 Shangraw, et. al., Pharmaceutical Technology Formulators’ preference for certain fillers/binders
00:40:54 Formulators’ preference for disintegrating agents
00:41:17 Formulators’ preference for certain lubricant levels
00:41:38 Excipients for direct compression
00:42:14 Key Factors: Particle Size and Shape
00:42:57 Ideal Material
00:44:10 Effects of Physical Properties for Starch Acetate Powders on Tableting*
00:44:54 Physical Properties and Compact Analysis of Commonly Used Direct Compression Binders*
00:45:33 Effect of Particle Size on Tablet Strength*
00:45:55 Common problems encountered during tablet manufacturing operations include
00:46:45 Determining factors for particle size of a tablet formulation
00:47:10 Determining factors for particle size of a tablet formulation
00:47:31 Fines
00:48:14 Untitled
This webinar describes the particle sizing needs for tabletting and the effect changes in particle size can have on the end product.