| 00:00:00 | Particle characterisation using Morphological imaging: Pharmaceutical applications |
| 00:02:19 | Overview |
| 00:03:31 | What is Morphological Imaging? |
| 00:04:34 | Why is particle size and shape important ? |
| 00:05:45 | Malvern Instrumentation |
| 00:07:27 | Morphological Imaging in the Pharmaceutical Development Cycle |
| 00:09:55 | Value of imaging to pharmaceutical industry |
| 00:11:31 | Application data Trouble shooting / manufacturing support - identifying batch differences |
| 00:11:42 | Difference in behaviour between Tap Milled vs Micronised excipient |
| 00:12:28 | Difference in Behavior |
| 00:13:25 | API Dissolution behaviour - Batch-to-batch |
| 00:14:00 | API Dissolution behaviour - Batch-to-batch |
| 00:14:50 | Identify Parameters that differentiate between Good and Bad Batches |
| 00:16:34 | Application data Research and Development |
| 00:16:45 | Assess Effect of dispersion pressure |
| 00:17:39 | Assess Effect of Dispersion Pressure |
| 00:18:33 | Assess Effect of dispersion pressure |
| 00:19:19 | Assess Effect of dispersion pressure |
| 00:20:05 | Assess Effect of dispersion pressure |
| 00:20:34 | Effect of Dispersion Conditions – Fragile APIs |
| 00:21:23 | Application data Regulation and Quality Control |
| 00:21:27 | Foreign Particulate Matter (FPM) |
| 00:22:47 | Parenterals USP 788 – Standard Report |
| 00:23:24 | QC - Identify Oversized API particles in Drug Suspension |
| 00:24:26 | QC - Identify Oversized API particles in Drug Suspension |
| 00:24:52 | QC – Biotherapeutics suspension |
| 00:26:00 | Application data Measuring individual components with in a formulation |
| 00:26:06 | Crystalline and Amorphous API |
| 00:26:54 | Crystalline and Amorphous API |
| 00:27:50 | Mixture of API and Starch |
| 00:28:49 | Application data Measuring PSD of the API in a formulation for Bioequivalence Comparisons |
| 00:29:01 | Nasal Spray – API Particle Size Distribution |
| 00:30:21 | Nasal Spray – API Particle Size Distribution |
| 00:31:43 | Nasal spray – Additional Verification by Morphologically Directed Raman Spectroscopy |
| 00:33:27 | Nasal Spray Formulation – API Size Distribution |
| 00:33:38 | Assess Bioequivalence Anti-inflammatory cream |
| 00:34:20 | Assess Bioequivalence: Injectable formulation |
| 00:35:19 | Application data Validating other sizing techniques |
| 00:35:26 | Validating other sizing techniques |
| 00:36:49 | Validating other sizing techniques |
| 00:38:02 | Validating other sizing techniques |
| 00:38:42 | Validating other sizing techniques |
| 00:39:14 | Validating other sizing techniques |
| 00:39:46 | Validating other sizing techniques |
| 00:40:57 | Summary |
| 00:41:54 | Contact Information |
This presentation will provide an overview of the different applications of automated particle imaging within the pharmaceutical research, development and production environments. This will be illustrated with a wide range of application examples.