Fecha registrada: September 10 2013

Duration: 44 minutes 13 seconds

In this webinar we look at the particle size distribution data generated by laser diffraction, and consider how these can be used to generate realistic product specifications.
Table of contents
1. Laser diffraction masterclass 5: Setting specifications
00:51
2. Masterclass 5: Specification setting
00:28
3. Laser diffraction measurement process
00:44
4. Laser Diffraction Masterclass
00:23
5. Overview
01:09
6. What is a specification?
01:17
7. What properties should be considered?
00:47
8. When should particle size be measured?
02:09
9. How should specifications be justified?
00:42
10. What should specifications be based on?
02:23
11. Understanding the results from a diffraction system
02:08
12. Typical laser diffraction results
00:28
13. Distribution statistics: Median and mode
00:21
14. Distribution statistics: Median and mode
00:48
15. Distribution statistics: Percentiles
01:00
16. Distribution statistics: Percentiles
00:38
17. Distribution statistics: Mean particle sizes
00:37
18. Distribution statistics: Mean particle size
01:11
19. Distribution statistics: Mean particle sizes
00:44
20. Distribution statistics: Sampling requirements
00:05
21. Distribution statistics: Sampling requirements
01:07
22. Definitions of measurement precision
01:39
23. What precision values are reasonable?
01:36
24. Setting a specification: Dissolution dynamics
01:53
25. Controlling the dissolution rate
00:56
26. Controlling the dissolution rate
00:44
27. Tracking changes in particle size
01:37
28. Controlling formulation stability: sedimentation
00:58
29. Controlling suspension rheology
00:34
30. How does particle size affect suspension rheology?
00:05
31. Factors affecting the tableting process
00:52
32. Forces of adhesion as a function of particle size
00:44
33. Specification example: Tablet formulation
00:51
34. Specification example: Tablet formulation
01:30
35. Specification example: Tablet formulation
02:22
36. Linking measurement data and manufacturing specifications
00:46
37. Conclusions
01:22
38. Questions
04:38
39. Thank you
00:39
40. Upcoming webinars
00:27