Fecha registrada: January 21 2014

Duration: 32 minutes 42 seconds

Biopharmaceutical impurities have long been associated with undesirable clinical reactions. It is essential, therefore, that the purity profiles of such drugs are characterized with the most sensitive analysis methods available. Dynamic light scattering is widely used for this purpose, due to its high sensitivity to larger particles, and its ability to resolve trace amounts of such particles from smaller entities (such as the API monomer). In addition, the DLS-derived dynamic virial coefficient can be used as a predictor of aggregation propensity, highly useful for formulation screening. This webinar will investgate how and why the Zetasizer range of instruments is widely used to carry out such types of analysis.
Table of contents
1. Untitled
01:08
2. Step into the Light – how Dynamic Light Scattering can Improve the Quality of your Biopharmaceutical DataMichael CavesProduct Technical Specialist for Biophysical Characterisation
00:20
3. Protein Evolution
00:48
4. Protein Structure
00:16
5. Biopharmaceutical Analysis
00:21
6. Biopharmaceutical Analysis
00:13
7. Untitled
00:30
8. Untitled
00:31
9. Untitled
00:02
10. Static Light Scattering (SLS)
00:23
11. Dynamic Light Scattering (DLS)
00:34
12. Untitled
00:19
13. Untitled
00:22
14. Untitled
00:14
15. Untitled
00:07
16. Untitled
00:02
17. Untitled
00:02
18. Untitled
00:26
19. The Correlogram
00:25
20. The Correlogram
01:14
21. Untitled
00:49
22. Untitled
02:20
23. Dynamic Light Scattering Theory Summary
00:26
24. Untitled
00:03
25. FDA Draft Guidance 2013 – Immunogenicity
00:25
26. Biopharmaceutical Stability
01:13
27. Monitor the Earliest Stages of Aggregation25.0 °C71.5 °C76.5 °C84.0 °C
01:29
28. Pegylation Analysis
01:55
29. Real-Time Aggregation
00:55
30. Antibody Binding Studies
00:54
31. Antibody Binding Studies
01:39
32. Purity and Stability Analysis Summary
00:26
33. Untitled
00:02
34. FDA Draft Guidance 2013 – Immunogenicity
00:37
35. Untitled
01:13
36. Untitled
00:51
37. Untitled
01:07
38. Orthogonal Stability Prediction
00:38
39. Stability Prediction Summary
00:18
40. Untitled
00:03
41. The Malvern Zetasizer Range
01:19
42. DLS Biopharmaceutical Applications
00:50
43. Thank You for ListeningQuestions?
04:07
44. Contact Information
00:46