| 00:00:00 | Particle size, Shape and Dissolution |
| 00:02:09 | Particle size, shape, and dissolution |
| 00:03:10 | Format |
| 00:04:11 | Abstract |
| 00:05:25 | Obligatory opening quotations |
| 00:06:27 | Introduction |
| 00:07:48 | M H Rubinstein “Particle Size Analysis as a Predictor of Dissolution Rate/Bioavailability” Anal. Proc. (London), 18, 512 - 514 (December 1981) |
| 00:08:19 | Heywood |
| 00:09:14 | Why measuring size is easier than relating to the final properties (Heywood) |
| 00:10:38 | Effect of size reduction for the same material MK-869 |
| 00:11:45 | Fundamental theory |
| 00:12:20 | Noyes-Whitney |
| 00:13:02 | Noyes-Whitney (MIT) |
| 00:14:01 | Basic simple equation |
| 00:15:12 | Adapted from Umesh V Banakar “Pharmaceutical Dissolution Testing” Informa Healthcare Drugs and the Pharmaceutical Sciences Series Volume 49 (2010) page 7 |
| 00:16:30 | “Modified” form |
| 00:17:33 | Noyes-Whitney |
| 00:18:32 | Effect of particle size on dissolution of Nevirapine tablets |
| 00:19:39 | Clearly the smaller the size, then the faster the dissolution |
| 00:20:31 | Prediction of solubility Basic Physical Chemistry – back to college |
| 00:21:48 | Prediction of solubility |
| 00:23:20 | Moore page 298 |
| 00:25:00 | Harry Brittain: 3.7 “Solubility Methods for the Characterization of New Crystal Forms” page 323 - 346 Editors: Moji Christianah Adeyeye & Harry G Brittain “Preformulation in Solid Dosage Form Development” Informa Healthcare Drugs and the Pharmaceutical Sc |
| 00:27:05 | Variables to control |
| 00:28:24 | Other factors controlling dissolution |
| 00:30:05 | Instrumental factors |
| 00:31:08 | Dissolution example |
| 00:31:39 | USP Study (2007) |
| 00:32:16 | Dissolved gas – after Bill Hanson William A Hanson “Handbook of Dissolution Testing” Pharmaceutical Technology Publications (1982) page 79 |
| 00:32:54 | Quality of vessel |
| 00:33:25 | Dissolution example |
| 00:34:10 | Solubility of Zidovudine at 25oC |
| 00:34:34 | Solubility of Artesunate |
| 00:34:53 | Decomposition of Artesunate in aqueous solution |
| 00:35:41 | So, what should we see with time? |
| 00:36:23 | Modification of the equation |
| 00:37:29 | Polydispersity |
| 00:37:56 | Single particle |
| 00:38:25 | Single Particle Example |
| 00:39:51 | Hypothesis |
| 00:40:51 | Relation of blood level concentration with size |
| 00:41:45 | Testing Methods |
| 00:42:50 | USP <711> |
| 00:43:22 | Basket and Paddle |
| 00:44:16 | Verification |
| 00:44:45 | USP <711> Intent to Revise |
| 00:45:07 | USP <711> |
| 00:45:35 | Harmonization |
| 00:46:11 | Verification |
| 00:46:29 | Type 3 dissolution apparatus Reciprocating Cylinder |
| 00:46:56 | Novel method using rheology |
| 00:47:59 | Be aware… |
| 00:48:44 | Early work on aspect ratio Carstensen |
| 00:49:39 | “Isometricity” |
| 00:50:04 | From Umesh V Banakar “Pharmaceutical Dissolution Testing” Informa Healthcare Drugs and the Pharmaceutical Sciences Series Volume 49 (2010) page 11 |
| 00:50:36 | Effect of shape/polymorphs |
| 00:51:41 | Snyder, Doherty (2007) |
| 00:52:28 | Polymorphs |
| 00:53:18 | Snyder, Doherty (2007) |
| 00:53:49 | Purdue/Abbott collaboration |
| 00:54:40 | Purdue/Abbott collaboration |
| 00:55:04 | Poorly soluble materials |
| 00:55:51 | Elaine M Merisko-Liversidge, G G Liversidge “Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds” Toxicologic Pathology, 36:43 – 48, (2008) |
| 00:56:37 | Reference List |
| 00:57:25 | References (contd.) |
| 00:57:52 | References |
| 00:58:09 | Summary |
| 00:58:58 | Thank you! |
| 00:59:27 | Contact Information |
Here we'll be discussing the important link between particle size and dissolution rate, with particular reference to the pharmaceutical industry. The importance of dissolution in relation to bioavialability assessment will be highlighted.