Launching new solution to accelerate biologics drug development
Biologics is an exciting – and important – field of drug discovery and research. Promising new treatments for cancer and immune-mediated inflammatory disease have emerged in recent years, giving hope to millions of patients across the globe. Besides enabling medical breakthroughs, powerful analysis techniques help drive scientific progress, including in health crises.
What can we do with the Creoptix® WAVEsystem?
The Creoptix® WAVEsystem combines crude sample robustness, high sensitivity, and intuitive software, to create a novel optical biosensor platform for real-time label-free binding kinetics. Engineered around innovative microfluidics and our proprietary Grating-Coupled Interferometry (GCI) technology, novel data from difficult samples is now possible for unsurpassed insight.
How is it different from similar technologies?
To get the information you need on drug stability and performance, you need to assess the properties in relevant sample matrices. Over the last years, label-free detection is gaining widespread acceptance as an important research and development tool, as it analyzes molecular interactions without using additional isotope or fluorescent labels.
Let’s focus on biologics!
Ligand Screening Wizard
A faster, flexible way to screen and characterize antibodies
Multiple analyte injection is the preferred method to screen for binding partners. However, this approach is not suitable for all biological systems. Kinetic analysis, for example, is best achieved when immobilizing the antibody on the surface and injecting the antigen as the analyte. It is important to maintain the same immobilization levels for all antibodies to ensure correct interpretation of the results, however.
The Ligand Screening Wizard allows easy and intuitive assay setup by creating a “ligand block”, where ligand samples are cycled through the biosensor surface in sequential capture/regeneration steps. This also helps avoid avidity effects and complex ligand regeneration steps.
The Ligand Screening Wizard works in perfect harmony with the “target level” function, ensuring that ligands are always captured at the same density level for correct data interpretation.
CFCA Wizard
A calibration-free approach to quantification
CFCA stands for “calibration-free concentration analysis”. It is a label-free based approach using the relationship between the diffusion properties of the analyte and the absolute analyte concentration.
The WAVEsystem allows you to measure the binding of an injected protein (analyte) to a binding partner immobilized on the surface (ligand) under diffusion-limiting conditions. The transport of the analyte to the sensor surface determines the observed binding rate. The system is said to be under mass transport limitation (MTL) and dose-response curves are independent of the binding affinity; instead, they are determined by the protein diffusion properties.
Join us at our virtual launch event to see how our latest developments and improvements will turbocharge your biologics discovery and development while simplifying and streamlining your workflow.