| 00:00:00 | Introduction to ARCHIMEDES “Mass Measurement on a Different Scale” |
| 00:02:29 | Agenda |
| 00:03:18 | 700 Malvern employees worldwide |
| 00:04:19 | The Biopharmaceutical Shift |
| 00:05:28 | Malvern’s Commitment to Biopharma |
| 00:07:17 | ARCHIMEDES Preview |
| 00:08:25 | How ARCHIMEDES Works |
| 00:08:32 | Technology: Resonant Mass Measurement |
| 00:08:55 | Measuring Particle Mass in Fluid |
| 00:09:37 | Measuring Particle Mass in Fluid |
| 00:10:02 | Sensors Fabricated via MEMS |
| 00:12:00 | ARCHIMEDES’ Instrumentation |
| 00:13:23 | ARCHIMEDES in Action |
| 00:13:51 | 2 Micron Particles |
| 00:14:19 | Particle Properties and Statistics |
| 00:14:56 | Superior Particle Metrology |
| 00:15:41 | ARCHIMEDES: a Complete System |
| 00:16:22 | ARCHIMEDES for Analysis of Protein Formulations |
| 00:16:29 | ARCHIMEDES Addresses a Key Size Range |
| 00:17:36 | ARCHIMEDES’ Analysis of Human IgG |
| 00:18:45 | Silicone Oil in Protein Formulations |
| 00:19:46 | ARCHIMEDES distinguishes silicone oil from protein by buoyancy |
| 00:20:42 | ProteinOilTurboTrace |
| 00:21:06 | Comparison of IFN-Beta Products for Multiple Sclerosis with Jim Barnard and John Carpenter, U. Colorado |
| 00:22:58 | ARCHIMEDES’ Analysis of Aggregates vs. Oil in IFN-Beta Products |
| 00:24:07 | Method Comparison |
| 00:25:10 | Development of Aggregates in Stressed Protein Formulations |
| 00:26:57 | Determining Particle Density |
| 00:28:35 | ARCHIMEDES’ Advantages for Protein Characterization |
| 00:30:01 | Further Applications of ARCHIMEDES |
| 00:30:11 | Nanoparticles: 57 nm + 100 nm Au |
| 00:30:48 | Bacteria and Cell Growth |
| 00:33:13 | References |
| 00:33:32 | For Further Information |
| 00:45:38 | Closing Slide |
An introduction to Archimedes, the technique of resonant mass measurement, and how this technology is vital in understanding and monitoring early aggregation events in your biopharmaceutical formulation