Understanding the properties of dry powder inhaler formulations through combined cascade impaction and automated image analysis measurements

Introducing a new approach for dry powder inhaler characterisation, which combines automated imaging and cascade impaction to measure the particle size and shape distributions for particles which have been aerosolized. This aids understanding of the dispersion of the formulation during device actuation.

In this note we show how the Morphologi automated imaging system can be used to understand the degree of powder dispersion achieved during the operation of a dry powder inhaler by analysing powder fractions collected using cascade impaction.

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